Promegapoietin

Promegapoietin

Promegapoietin is a drug given during chemotherapy to increase blood cell regeneration. It is a colony-stimulating factor that stimulates megakaryocyte production. [cite journal |author=Kratz-Albers K, Scheding S, Möhle R, Bühring H, Baum C, Mc Kearn J, Büchner T, Kanz L, Brugger W |title=Effective ex vivo generation of megakaryocytic cells from mobilized peripheral blood CD34(+) cells with stem cell factor and promegapoietin |journal=Exp Hematol |volume=28 |issue=3 |pages=335–46 |year=2000 |pmid=10720698 |doi=10.1016/S0301-472X(99)00152-6] [ [http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=46019 Definition of promegapoietin - NCI Dictionary of Cancer Terms ] ]

It functions by stimulating ligands for interleukin 3 and c-Mpl. [cite journal |author=Doshi P, Giri J, Abegg A, Favara J, Huynh M, Kahn L, Minnerly J, Pegg L, Villani-Price D, Siegel N, Staten N, Thomas J, McKearn J, Smith W |title=Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways |journal=Exp Hematol |volume=29 |issue=10 |pages=1177–84 |year=2001 |pmid=11602319 |doi=10.1016/S0301-472X(01)00694-4]

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Look at other dictionaries:

  • promegapoietin — A drug given during chemotherapy to increase blood cell regeneration. Promegapoietin is a colony stimulating factor that stimulates the production of blood cells, especially platelets. It is a cytokine and belongs to the family of drugs called… …   English dictionary of cancer terms

  • List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia

  • Colony-stimulating factor — Colony stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate… …   Wikipedia

  • colony-stimulating factor — A substance that stimulates the production of blood cells. Colony stimulating factors include granulocyte colony stimulating factor (G CSF), granulocyte macrophage colony stimulating factor (GM CSF), and promegapoietin …   English dictionary of cancer terms

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