Andrew Jess Dannenberg

Andrew Jess Dannenberg (born 17 February 1956) is a U.S. physician and researcher, currently Henry R. Erle, M.D. - Roberts Family Professor of Medicine at Weill Medical College/M.D. Anderson Cancer Center. He additionally holds the positions there of Professor of Medicine in Cardiothoracic Surgery and Director of Cancer Prevention. He received a B.s. from Tufts University in 1978 and a M.D. from Washington University School of Medicine in 1982.

NSAIDs and cancer controversy

In January 2006, it was revealed that an article ("The Lancet", October 2005) he had co-authored with Norwegian researcher Jon Sudbø was a scientific misconduct and retracted. [cite news |first=Richard |last=Horton |authorlink= |coauthors= |title=Retraction — Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study|url= |quote=|publisher=The Lancet |date=4 February, 2006 |accessdate=2008-03-26 ] The paper had reported on the side effects of other NSAIDs on oral cancer, saying "Our findings highlight how a commonly used drug can have a benefit from the standpoint of cancer prevention but can also have side effects - in this case, an increased risk for cardiovascular death ..." [cite news |first= |last= |authorlink= |coauthors= |title=Use Of Non-COX-2-specific NSAIDs Halves Odds For Oral Cancer: Doubles Cardiovascular Death Risk |url=http://www.sciencedaily.com/releases/2005/10/051007083413.htm |quote=An analysis of 20 years of data on the health of over 900 adults has found that long-term use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, cuts the risk for oral cancer in smokers by half. |publisher=Science Daily |date=October 7, 2005 |accessdate=2008-03-26 ] [cite news |first=Andrew |last=Dannenberg| authorlink= |coauthors= |title= Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study|url=http://www.ncbi.nlm.nih.gov/pubmed/16226613 |quote=Non-steroidal anti-inflammatory drugs (NSAIDs) seem to prevent several types of cancer, but could increase the risk of cardiovascular complications. We investigated whether use of NSAIDs was associated with a change in the incidence of oral cancer or overall or cardiovascular mortality. |publisher=The Lancet |date=October 15, 2005 |accessdate=2008-03-26 ] [cite news |first= |last= |authorlink= |coauthors= |title=Fraud charges against Norwegian researcher stoke confusion over painkillers |url= |quote=Fraud accusations against a Norwegian researcher have muddied the question of whether popular over-the-counter pain relievers fight cancer or harm the heart. Norway's Comprehensive Cancer Center said over the weekend that one of its researchers admitted fabricating data used in a study that said common pain relievers, including ibuprofen (sold as Motrin and Advil) and naproxen (Naprosyn, Aleve), lowered the risk of oral cancer but heightened the risk of heart problems.... |publisher=Associated Press |date=January 17, 2006 |accessdate=2008-03-26 ]

According to the Norwegian daily "Verdens Gang", Dannenberg may have been instrumental in the conception of the article ( [http://www.vg.no/pub/vgart.hbs?artid=138544] , in Norwegian). An independent Commission of Inquiry led by Swedish Professor Anders Ekbom found no evidence that any of his co-authors had taken part in the fraud or otherwise been party to the deceit. [Cite news
first = Staffan
last = Kihlström
url = http://www.dn.se/DNet/jsp/polopoly.jsp?d=597&a=542859
title = 60 forskare granskas efter fuskskandal
language = Swedish
publisher = Dagens Nyheter
date = 2006-05-06]

Honors

*Upjohn Achievement Award for scientific research
*American Liver Foundation Scholar Award and the
*International Life Sciences Research Foundation Award.

Publications

His current work deals with the role of cyclooxygenase-2 (COX-2) in cancer. [" COX-2 Inhibitors for Cancer Prevention & Treatment: Research Roundup: " by Lindsey, Heather [http://www.oncology-times.com/pt/re/oncotimes/fulltext.00130989-200204000-00023.htm;jsessionid=HqTdZwfthL02hGykTysZyphbZpWFdFZGZtpKgM17QNLvkLQn2VTn!923867264!181195629!8091!-1 Oncology Times] ] , [" COX-2 Inhibitors: Cancer Trials Test New Uses for Pain Drug" by Jennifer Michalowski [http://jnci.oxfordjournals.org/cgi/content/full/94/4/248 Journal of the National Cancer Institute] 24(4)April 2002p 52-54] , ["Researchers Plan To Continue To Study COX-2 Inhibitors in Cancer Treatment and Prevention" by Cori Vanchieri. [http://jnci.oxfordjournals.org/cgi/content/full/97/8/552. JNCI Spectrum] (with portrait) ] He has previously been one of the three lead investigators of a major study on the role of aspirin in the prevention of breast cancer. [ "Women who regularly take aspirin at lower risk of breast cancer" [http://www.news-medical.net/?id=2016 Women's Health News] Monday, 31-May-2004] .

Journals

According to Web of Science, he has published over 200 peer-reviewed articles, of which 27 have cited over 100 times. The most cited are:
*"Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis" by Boolbol SK, Dannenberg AJ, Chadburn A, in "Cancer Research" 56(11)2556-2560 (1996) Times Cited: 401
*"Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer" by Tucker ON, Dannenberg AJ, Yang FK, et al. in "Cancer Research" 59 (5) 987-990 (1999)Times Cited: 386
*"Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck" by Chan G, Boyle JO, Yang EK, et al. in "Cancer Research" 59 (5) 991-994 (1999) Times Cited: 384
*"COX‐2 is expressed in human pulmonary, colonic, and mammary tumors" RA Soslow, AJ Dannenberg, D Rush, BM Woerner, KN. in "Cancer": 89 ( 12) 2637-2645 (2000) Times Cited: 289

Editor

*"COX-2: A New Target for Cancer Prevention and Treatment " ed. by R. N. Dubois and A. J. Dannenberg Basel ; New York : Karger, 2003. ISBN: 380557536X 978380557536
*"The role of COX-2 carcinogenesis" by Andrew J Dannenberg; Raymond N Dubois; Steven M Dubinett; Nasser K Altorki; et al Philadelphia, PA : Saunders, 2004. OCLC: 66570293
*"Peptic ulcer disease and other acid-related disorders" by David Zakim; Andrew J Dannenberg Armonk, N.Y. : Academic Research Associates, 1991. ISBN: 9780962918001

References

External links

* [http://www.cornellphysicians.com/andrewdannenberg/ Andrew Jess Dannenberg] - homepage at Cornell university