Mitotic index

Mitotic index

Mitotic index is a measure for the proliferation status of a cell population. It is defined as the ratio between the number of cells in mitosis and the total number of cells. The mitotic index is an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer. It may lose much of its predictive value for elderly populations, for example a low mitotic index loses any prognostic value for women over 70 years with breast cancer.[1]

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  1. ^ Baak, J. P. A.; Gudlaugsson, E.; Skaland, I.; Guo, L. H. R.; Klos, J.; Lende, T. H.; Søiland, H. V.; Janssen, E. A. M. et al. (2008). "Proliferation is the strongest prognosticator in node-negative breast cancer: Significance, error sources, alternatives and comparison with molecular prognostic markers". Breast Cancer Research and Treatment 115 (2): 241–254. doi:10.1007/s10549-008-0126-y. PMID 18665447.  edit

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  • mitotic index — mitotic index. См. митотический индекс. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • mitotic index — n the number of cells per thousand cells actively dividing at a particular time * * * the proportion of cells in a tissue that are dividing at a given time. * * * an expression of the number of cells in a population undergoing mitosis, either as… …   Medical dictionary

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  • mitotic index — noun : the number of cells per thousand cells actively dividing at a particular time * * * mitotic index noun The proportion in any tissue of dividing cells, usu expressed as per thousand cells • • • Main Entry: ↑mitosis …   Useful english dictionary

  • mitotic index — The fraction of cells in a sample that are in mitosis. It is a measure of the relative length of the mitotic phase of the cell cycle …   Dictionary of molecular biology

  • mitotic index — the proportion of cells in a tissue that are dividing at a given time …   The new mediacal dictionary

  • mitotic index — In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis …   English dictionary of cancer terms

  • Индекс Митотический (Mitotic Index) — число клеток, которые в данный момент времени находятся в процессе митоза. Источник: Медицинский словарь …   Медицинские термины

  • index — 1. [NA] SYN: i. finger. 2. A guide, standard, indicator, symbol, or number denoting the relation in respect to size, capacity, or function, of one part or thing to another. SEE ALSO: quotient, r …   Medical dictionary

  • centromeric index — the ratio of the length of the shorter arm of a mitotic chromosome to the total length of the chromosome …   Medical dictionary

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