HMB-45

HMB-45

HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas. It is used in anatomic pathology as a marker for such tumors.

HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. [cite journal |author=Gown AM, Vogel AM, Hoak D, Gough F, McNutt MA |title=Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes |journal=Am. J. Pathol. |volume=123 |issue=2 |pages=195–203 |year=1986 |pmid=3518473 |doi=] The antibody was generated to an extract of melanoma. It reacted positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, the antibody reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. HMB stands for Human Melanoma Black.

References

External links

* [http://www.scbt.com/datasheet-59305-melanoma-marker-hmb45-antibody.html Melanoma Marker (HMB45) Antibody] - www.scbt.com
* [http://www.abcam.com/index.html?datasheet=787 Melanoma antibody (ab787) datasheet] - abcam.com.


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