Pharmaceuticals in India

Pharmaceuticals in India

The first Indian pharmaceutical company, Bengal Chemicals and Pharmaceutical Works, which still exists today as one of 5 government-owned drug manufacturers, appeared in Calcutta in 1930. For the next 60 years, most of the drugs in India were imported by multinationals either in fully-formulated or bulk form. The government started to encourage the growth of drug manufacturing by Indian companies in the early 1960s, and with the [http://www.ircc.iitb.ac.in/IPcourse/patent.html Patents Act in 1970] , enabled the industry to become what it is today. This patent act removed composition patents from food and drugs, and though it kept process patents, these were shortened to a period of five to seven years. The lack of patent protection made the Indian market undesirable to the multinational companies that had dominated the market, and while they streamed out, Indian companies started to take their places. They carved a niche in both the Indian and world markets with their expertise in reverse-engineering new processes for manufacturing drugs at low costs. Although some of the larger companies have taken baby steps towards drug innovation, the industry as a whole has been following this business model until the present.

The Indian pharmaceutical industry (IPo) today

tatistics

In 2002, over 20,000 registered drug manufacturers in India sold $9 billion worth of formulations and bulk drugs. 85% of these formulations were sold in India while over 60% of the bulk drugs were exported, mostly to the United States and Russia [25] . Most of the players in the market are small-to-medium enterprises; 250 of the largest companies control 70% of the Indian market [http://www.pharmaceutical-drug-manufacturers.com/] . Thanks to the 1970 Patent Act, multinationals represent only 35% of the market, down from 70% thirty years ago [20] .

Most pharma companies operating in India, even the multinationals, employ Indians almost exclusively from the lowest ranks to high level management. Mirroring the social structure, firms are very hierarchical. Homegrown pharmaceuticals, like many other businesses in India, are often a mix of public and private enterprise. Although many of these companies are publicly owned, leadership passes from father to son and the founding family holds a majority share.

In terms of the global market, India currently holds a modest 1-2% share, but it has been growing at approximately 10% per year [27] . India gained its foothold on the global scene with its innovatively-engineered generic drugs and active pharmaceutical ingredients (API), and it is now seeking to become a major player in outsourced clinical research as well as contract manufacturing and research. There are 74 U.S. FDA-approved manufacturing facilities in India, more than in any other country outside the U.S, and in 2005, almost 20% of all Abbreviated New Drug Applications (ANDA) to the FDA are expected to be filed by Indian companies [21,27] . Growth in other fields notwithstanding, generics are still a large part of the picture. London research company Global Insight estimates that India’s share of the global generics market will have risen from 4% to 33% by 2007 [27] .

Patents

As it expands its core business, the industry is being forced to adapt its business model to recent changes in the operating environment. The first and most significant change was the January 1, 2005 enactment of an amendment to India’s patent law that reinstated product patents for the first time since 1972. The legislation took effect on the deadline set by the WTO’s Trade-Related Aspects of Intellectual Property Rights (TRIPS) agreement, which mandated patent protection on both products and processes for a period of 20 years. Under this new law, India will be forced to recognize not only new patents but also any patents filed after January 1 1995 [http://www.wto.org/english/thewto_e/whatis_e/tif_e/agrm7_e.htm] . Indian companies achieved their status in the domestic market by breaking these product patents, and it is estimated that within the next few years, they will lose $650 million of the local generics market to rightful patent-holders [42] .

In the domestic market, this new patent legislation has resulted in fairly clear segmentation. The multinationals narrowed their focus onto high-end patients who make up only 12% of the market, taking advantage of their newly-bestowed patent protection. Meanwhile, Indian firms have chosen to take their existing product portfolios and target semi-urban and rural populations [45] .

The new patent regime to have taken effect at a time when Indian companies had recently started to aggressively pursue global opportunities, so it is not clear whether the flurry of international activity surrounding the enactment date is a result of the change in legislation. Mergers, acquisitions and alliances have been taking place on an unprecedented scale, most notably with companies in the U.S. and Europe. As stated in The Hindu Business Line, “In the last 10-odd months, the Indian pharma industry has possibly seen the single largest number of global transactions in its 50-year history.” These transactions provide Indian companies with access to foreign markets and facilitate the process of seeking regulatory approval for new products, which can be quite daunting for a company that only has operations on Indian soil. [10]

Product development

Companies are also starting to adapt their product development processes to the new environment. For years, firms have made their ways into the global market by researching generic competitors to patented drugs and following up with litigation to challenge the patent. This approach remains untouched by the new patent regime and looks to increase in the future. However, those that can afford it have set their sights on an even higher goal: new molecule discovery. Although the initial investment is huge, companies are lured by the promise of hefty profit margins and the recognition as a legitimate competitor in the global industry. Local firms have slowly been investing more money into their R&D programs or have formed alliances to tap into these opportunities.

mall and medium enterprises

As promising as the future is for a whole, the outlook for small and medium enterprises (SME) is not as bright. The excise structure changed so that companies now have to pay a 16% tax on the maximum retail price (MRP) of their products, as opposed to on the ex-factory price. Consequently, larger companies are cutting back on outsourcing and what business is left is shifting to companies with facilities in the four tax-free states - Himachal Pradesh, Jammu & Kashmir, Uttaranchal and Jharkhand. [12]

As SMEs wrestled with the tax structure, they were also scrambling to meet the July 1 deadline for compliance with the revised Schedule M Good Manufacturing Practices (GMP). While this should be beneficial to consumers and the industry at large, SMEs have been finding it difficult to find the funds to upgrade their manufacturing plants, resulting in the closure of many facilities. Others invested the money to bring their facilities to compliance, but these operations were located in non-tax-free states, making it difficult to compete in the wake of the new excise tax.

Challenges

All of these changes are ultimately good for the Indian pharmaceutical industry, which suffered in the past from inadequate regulation and large quantities of spurious drugs. They force the industry to reach a level necessary for global competitiveness. However, they have also exposed some of the inadequacies in the industry today. Its main weakness is an underdeveloped new molecule discovery program. Even after the increased investment, market leaders such as Ranbaxy and Dr. Reddy’s Laboratories spent only 5-10% of their revenues on R&D, lagging behind Western pharmaceuticals like Pfizer, whose research budget last year was greater than the combined revenues of the entire Indian pharmaceutical industry [13, 37] . This disparity is too great to be explained by cost differentials, and it comes when advances in genomics have made research equipment more expensive than ever. The drug discovery process is further hindered by a dearth of qualified molecular biologists. Due to the disconnect between curriculum and industry, pharmas in India also lack the academic collaboration that is crucial to drug development in the West [13] .

R&D

Both the Indian central and state governments have recognized R&D as an important driver in the growth of their pharma businesses and conferred tax deductions for expenses related to research and development. They have granted other concessions as well, such as reduced interest rates for export financing and a cut in the number of drugs under price control. Government support is not the only thing in Indian pharma’s favor, though; companies also have access to a highly-developed IT industry that can partner with them in new molecule discovery.

Labor force

India’s greatest strengths lie in its people [see http://en.wikipedia.org/wiki/India] . India also boasts a cheap, well-educated, English-speaking [only a percentage, see http://en.wikipedia.org/wiki/Official_languages_of_India] labor force that is the base of its competitive advantage. Although molecular biologists are in short supply, there are a number of talented chemists who are equally as important in the discovery process. In addition, there has been a reverse brain-drain effect in which scientists are returning from abroad to accept positions at lower salaries at Indian companies. Once there, these foreign-trained scientists can transfer the benefits of their knowledge and experience to all of those who work with them [13,25] . India’s wealth of people extends benefits to another part of the drug commercialization process as well. With one of the largest and most genetically diverse populations in any single country, India can recruit for clinical trials more quickly and perform them more cheaply than countries in the West [47] . Indian firms have just recently started to leverage. (Indian companies spend the highest amount of money on R&D?)

Biotechnology

Relationship between pharmaceuticals and biotechnology

Unlike in other countries, the divide between biotechnology and pharmaceuticals remains fairly defined in India. Biotech there still plays the role of pharma’s little sister, but many outsiders have high expectations for the future. India accounted for 2% of the $41 billion global biotech market and in 2003 was ranked 3rd in the Asia-Pacific region and 11th in the world in number of biotechs. [45] In 2004-5, the Indian biotech industry saw its revenues grow 37% to $1.1 billion. [2,9] The Indian biotech market is dominated by biopharmaceuticals; 75% of 2004-5 revenues came from biopharmaceuticals, which saw 30% growth last year. Of the revenues from biopharmaceuticals, vaccines led the way, comprising 47% of sales [46] . Biologics and large-molecule drugs tend to be more expensive than small-molecule drugs, and India hopes to sweep the market in biogenerics and contract manufacturing as drugs go off patent and Indian companies upgrade their manufacturing capabilities.

Biotechnology statistics

Comparison with the U.S.

The Indian biotech sector parallels that of the U.S. in many ways. Both are filled with small start-ups while the majority of the market is controlled by a few powerful companies. Both are dependent upon government grants and venture capitalists for funding because neither will be commercially viable for years. Pharmaceutical companies in both countries have recognized the potential effect that biotechnology could have on their pipelines and have responded by either investing in existing start-ups or venturing into the field themselves. [36] In both India and the U.S., as well as in much of the globe, biotech is seen as a hot field with a lot of growth potential.

Relationship with IT

Many analysts have observed that the hype around the biotech sector mirrors that of the IT sector. Biotech colleges have been popping up around the country eager to service the pools of students that want to take advantage of a growing industry. [7] The International Finance Commission, the private investment arm of the World Bank, called India the “centerpiece of IFC’s global biotech strategy.” Of the $110 million invested in 14 biotech projects investment globally, the IFC has given $43 million to 4 projects in India. [29] According to Dr. Manju Sharma, former director of the Department of Biotechnology, the biotech industry could become the “single largest sector for employment of skilled human resource in the years to come.” [5] British Prime Minister Tony Blair was similarly impressed, citing the success of India’s biotech industry as the reason for his own country’s own biotech opportunities. [22] Malaysia is also looking to India as an example for growing its own biotech industry. [41]

Government support

The Indian government has been very supportive. It established the Department of Biotechnology in 1986 under the Ministry of Science and Technology. [47] Since then, there have been a number of dispensations offered by both the central government and various states to encourage the growth of the industry. India’s science minister launched a program that provides tax incentives and grants for biotech start-ups and firms seeking to expand and establishes the Biotechnology Parks Society of India to support ten biotech parks by 2010. Previously limited to rodents, animal testing was expanded to include large animals as part of the minister’s initiative. [10] States have started to vie with one another for biotech business, and they are offering such goodies as exemption from VAT and other fees, financial assistance with patents and subsidies on everything ranging from investment to land to utilities [19] .

Foreign investment

The government has also taken steps to encourage foreign investment in its biotech sector. An initiative passed earlier this year allowed 100% foreign direct investment without compulsory licensing from the government1. [6] In April, a delegation headed by the Kapil Sibal, the minister of science and technology and ocean development, visited five cities in the U.S. to encourage investment in India, with special emphasis on biotech. [32] Just two months later, Sibal returned to the U.S. to unveil India’s biotech growth strategy at the BIO2005 conference in Philadelphia. [9]

Challenges

The biotech sector faces some major challenges in its quest for growth. Chief among them is a lack of funding, particularly for firms that are just starting out. The most likely sources of funds are government grants and venture capital, which is a relatively young industry in India. Government grants are difficult to secure, and due to the expensive and uncertain nature of biotech research, venture capitalists are reluctant to invest in firms that have not yet developed a commercially viable product. [26] As previously mentioned, India hopes to solve its funding problem by attracting overseas investors and partners. Before these potential saviors will invest significant sums in the industry, however, there needs to be better scientific and financial accountability. India is slowly working towards these goals, but it will be a while before they are up to the standards of Western investors.

India’s biotech firms share another problem with their pharmaceutical cousins: a lack of qualified employees. Biotech has the additional disadvantage of competing against IT for ambitious, science-minded students but not being able to guarantee the same compensation. An aspiring researcher in India needs 7-10 years of education covering a range of specialties in order to qualify to work in biotech. Even if a student does choose to go on the biotech path, the ineffectual curriculum at many universities makes it doubtful as to whether he will be qualified to work in the field once finished. One estimate shows that 10% of upper-echelon biotech recruits have come from foreign countries. While this is not a problem, per se, it drives up cost in a country whose competitive advantage is based on cheap, high-quality labor. Far from ending with scientists, there is also a shortage of people with a knowledge of biotechnology in related fields: doctors, lawyers, programmers, marketing personnel and others. [7,15,17]

While little has been done about the latter half of the employee crunch, the government has addressed the problem of educated but unqualified candidates in its Draft National Biotech Development Strategy. This plan included a proposal to create a National Task Force that would work with the biotech industry to revise the curriculum for undergraduate and graduate study in life sciences and biotechnology. The government’s strategy also stated intentions to increase the number of PhD Fellowships awarded by the Department of Biotechnology to 200 per year. These human resources will be further leveraged with a “Bio-Edu-Grid” that will knit together the resources of the academic and scientific industrial communities, much as they are in the U.S. [5]

Major players

:Ranbaxy Laboratories:Sri S T Kalairaj, Chairman

Ranbaxy is the leader in the Indian pharmaceutical market, taking in $1.174 billion in revenues for a net profit of $160 million in 2004. It was the first Indian pharmaceutical to have a proprietary drug (extended-release ciproflaxin, marketed by Bayer) approved by the U.S. FDA, and the U.S. market accounts for 36% of its sales. 78% of Ranbaxy’s sales are from overseas markets; its offices in 44 countries manage manufacturing in 7 countries and distribution in over 100.

IMS Health estimated that Ranbaxy is among the top 100 pharmaceuticals in the world and that it is the 15th fastest growing company. By 2012, Ranbaxy hopes to be one of the top 5 generics producers in the world, and it consolidated its position with the purchase of French firm RGP Aventis in 2003. Ranbaxy also has higher aspirations, however, “to build a proprietary prescription business in the advanced markets.” To this end, it keeps a dedicated research facility in Gurgaon staffed with over 1100 scientists. They currently have two molecules in Phase II trials and 3-5 in pre-clinical testing. It spent $75 million in R&D in 2004, a 43% increase over its 2003 expenditure.

CEO Brian Tempest is the only non-Indian on the senior management team.38,39

:Dr. Reddy's Laboratories:K. Anji Reddy, Chairman

Founded in 1984 with $160,000, Dr. Reddy’s was the first Asia-Pacific pharmaceutical outside of Japan and the sixth Indian company to be listed on the New York Stock Exchange. It earned $446 million in fiscal year 2005, deriving 66% of this income from the foreign market. In order to strengthen its global position, Dr. Reddy acquired UK-based BMS Laboratories and subsidiary Meridian Healthcare.

Although 58% of Dr. Reddy’s revenues come from generic drugs, the company was committed to WTO-compliance long before the 2005 bill took effect, and most of these products were already off patent. Dr. Reddy has long been a research-oriented firm, preceding many of its peers in setting up a New Drug Development Research (NDDR) in 1993 and out-licensing its first compound just four years later. Dr. Reddy’s has since outlicensed two more molecules and currently has three others in clinical trials.

Although Dr. Reddy’s is publicly-traded, the Reddy family (including founder/chairman K. Anji Reddy, son-in-law/CEO GV Prasad and son/COO Satish Reddy) holds a hefty 26% share in the company.11,44

:Nicholas Piramal:Asish Mishra, Chairman

Now a company grossing $350 million per year, Nicholas Piramal started its existence with the 1988 acquisition of Nicholas Laboratories and grew through a series of mergers, acquisitions and alliances. The company has formed a name for itself in the field of custom manufacturing. It cites its 1700-person global sales force as another core strength; with its acquisition of Rhodia’s inhalation anaesthetics business, Nicholas Piramal gained a sales and marketing network spanning 90 countries34.

Nicholas Piramal is well-poised for the challenge of surviving in the aftermath of product patent protection. The company has respected intellectual property rights since its inception and refused to “support generic companies seeking first-to-file or early-to-market strategies.” Instead, it decided to make its own intellectual property and opened a research facility last November in Mumbai with hopes of launching its first drug in 2010 at a cost of $100,000.24,33

:Cipla:Dr. Yusuf K. Hamied, Chairman and Managing Director

Cipla burst into the international consciousness in 2000 with Triomune, an AIDS treatment costing between $300 and $800 per year that infringed upon patents held by several companies who were selling the cocktail for $12,000 per year. Long before this news, Cipla had been building a strong global presence, and it now distributes its 800-odd products in over 140 countries. Privately-held Cipla holds a prominent spot in its home country as well; it is the leader in domestic sales, having just unseated GlaxoSmithKline for the first time in 28 years. Revenue in 2004 totaled $552 million (using Rs 43.472 = $1) about 75% of which was derived in India. Cipla did not report having a research program.8,18

:Biocon:Dr. Kiran Mazumdar-Shaw, Chairman and Managing Director

Originally an extension to an Irish chemicals company seeking to break into the Indian market, Biocon is now the leading biotech in India, bringing in Rs 646.36 crore (almost $150 million) in revenue for fiscal year 2004. It initially made its money by producing enzymes, but Biocon recently decided to become a research-oriented company with the goal of bringing a proprietary new drug to market.

The company went public in March 2004, and “its shares were oversubscribed by 33 times on opening day.” Eight months later it launched Insugen, a bio-insulin that is its first branded product. Biocon also has two wholly-owned subsidiaries, Syngene and Clinigene, that perform custom research and clinical trials.3,14,31

: [http://www.seruminstitute.com Serum Institute of India] :Dr. Cyrus Poonawalla, Chairman

The Serum Institute of India can make the enviable claim that 2 out of every 3 children in the world are immunized with one of their vaccines. It is the world’s largest producer of measles and DTP vaccines, and its portfolio includes other vaccines, antisera, plasma products and anticancer compounds. The Serum Institute earned Rs 565 crore ($130 million) in revenue in fiscal year 2005, selling mainly to UN agencies and to the Indian government. The Serum Institute is part of the Poonawalla Group, whose holdings include a horse stud farm and manufacturers of industrial equipment and components.1,4,40

Other important domestic companies

:Intas Biopharmaceuticals:Dr. Urmish Chudgar, Managing Director

: [http://www.bharatserums.com/ Bharat Serums] :Mr. Bharat V. Daftary, Chairman and Managing Director

:Lupin Laboratories:Dr. Desh Bandhu Gupta, Chairman

:Orchid Pharmaceuticals:Mr. R. Narayanan, Chairman

: [http://www.panacea-biotec.com/ Panacea Biotech] :Mr. Soshil Kumar Jain, Chairman

:Sun Pharmaceuticals:Dilip S. Shangvi, Chairman and Managing Director

:Torrent Pharmaceuticals:Sudir Mehta, Chairman

:Wockhardt:Habil F. Khorakiwala, Chairman

:Cadila Healthcare:Pankaj R. Patel, Chairman and Managing Director

References

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2 "50% of country's biotech firms based in Karnataka." The Economic Times 23 April 2005.

3 Biopharmaceutical and Biotechnology Company. Biocon. 26 July 2005 .

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10 Datta, P.T. Jyothi. “More global buys by pharma cos likely.” The Hindu Business Line (Internet Edition), 22 July 2005.

11 Dr. Reddy Laboratories Ltd. Dr. Reddy’s Laboratories Ltd. 27 July 2005 .

12 D’Silva, Jeetha. “Pharma SMEs gasp for breath as big companies move to better climes.” The Economic Times 28 May 2005.

13 Dyer, Jeff and Khozem Merchant. “An experiment in globalization: how India hopes to reshape the world drugs industry.” Financial Times 18 August 2004: 15.

14 Egan, Mary Ellen. "Big Shot in Bangalore. (Kiran Mazumdar-Shaw )." Forbes 174:8 (18 October 2004): 88.

15 Ghatak, Lopamudra. “Fat pay, yuppie lifestyle - join biotech, not IT." Asia Africa Intelligence Wire 15 March 2005.

16 “Government to allow 100% FDI in Biotech (Biotech will be exempted from the requirement of compulsory licensing) ” India Business Insight - Global Newswire – Asia Africa Intelligence Wire 31 May 2005.

17 Hector, Darlington Jose. "NRIs, expats fuel biotech boom in India." The Economic Times 20 April 2005.

18 Hoovers Company Records – In-Depth Records: Cipla. 26 July 2005. Lexis-Nexis Academic Universe. 28 July 2005.

19 "Incentives for bio-tech units." Asia Africa Intelligence Wire 2 July 2005.

20 “India industry: Desperate for quality healthcare services.” Economist Intelligence Unit: Country ViewsWire. 24 June 2005.

21 Indiainfoonline.com. Indian Pharmaceutical Sector: Big Pharma Opportunity. By Atul Rastogi and Abhimanyu Verma. 28 August 2003.

22 “India’s biotech strides prompts UK to hike funds in sector.” Nationwide International News (The Press Trust of India) 7 March 2005.

23 “Intellectual property: protection and enforcement.” WTO: Understanding the WTO. World Trade Organization. 1 August 2005

24 Jarvis, Lisa. "NPIL sets ambitious growth targets." Chemical Market Reporter 267:16 (18 April 2005): 32-33.

25 Joshi, Hemant N. “Analysis of the Indian pharmaceutical industry: with emphasis on opportunities in 2005.” Pharmaceutical Technology 27:1 (2003): 74-84.

26 Kathuria, Vinish & Vandita Tewari. "Venture capitalists and biotech sector: Discovering the potential." Asia Africa Intelligence Wire 29 December 2004.

27 Kripalani, Manjeet. "Pharma Karma; Tougher patent protection laws are spurring rapid growth in new drug research across India." Business Week 39:29 (18 April 2005): 20.

28 Krishnan, Unni. “India enters a new era.” Manufacturing Chemist 76:2 (2005): 27-29.

29 Ludwina, Joseph. “IFC Committed to Support Indian Biotech Sector.” International Finance Corporation: Press Releases South Asia. 20 June 2005.

30 Malhotra, Prabodh & Lofgren, Hans. “India's pharmaceutical industry: hype or high tech take-off?” Australian Health Review 28:2 (2004): 182-193.

31 Mazumdar, Sudip. “First Lady; In Asia: India’s top biotech CEO begs to differ with those who say Singapore leads the field.” Newsweek International 11 October 2004: 39.

32 Na, K. Oanh. "India's sales pitch to Silicon Valley." San Jose Mercury News 12 April 2005.

33 Nicholas Piramal India Limited. Nicholas Piramal India Limited. 26 July 2005. .

34 “NPIL buys Rhodia business for 7m [pounds sterling] .” ACN: Asian Chemical News 11:475 (17 January 2005): 6.

35 Pharmaceutical and Drug Manufacturers Homepage. Pharmaceutical and Drug Manufacturers. 30 July 2005 .

36 Prasad, Girish Chandra. "Outlook improves for India's biotechnology sector." The Economic Times 31 December 2004.

37 “R and D spend of top 5 Indian pharmaceutical companies touches Rs1,000 crore.” Asia Africa Intelligence Wire 17 February 2005.

38 Ranbaxy – Indian Pharma Research & Pharmaceutical Company India. Ranbaxy Laboratories Ltd. 26 July 2005 .

39 Ranbaxy Laboratories Ltd. Annual Report. Gurgaon, India: Ranbaxy Laboratories Ltd. (2004).

40 Serum Institute of India. Serum Institute of India. 29 July 2005 < http://www.seruminstitute.com>.

41 Singh, Karamjit. “Net value: Tapping biotech know-how.” The Edge Malaysia 16 May 2005.

42 Singh, Seema. “India kicks the habit; local drugmakers have built a thriving industry on pilfering patents. The party ends in January.” Newsweek International (22 November. 2004): 56.

43 Sridharan, R. et al. “Indian pharma’s mid-life crisis.” Business Today 27 February. 2005: 50.

44 Tanzer, Andrew. “Pill factory to the world.” Forbes (internet) 10 December 2001. 29 July 2005.

45 Unnikrishnan, C H. “Patents carve up drug market.” Business Standard 29 July 2005.

46 “Vaccines push BioPharma sales.” BioSpectrum 3:6 (June 2005): 70-71.

47 Wilkie, Dana. “India wants to be your biotech source.” The Scientist 25 October 2004: 51-53.

48 Zinnov, "Pharmaceutical Outsourcing in India" .

See also

* Medicine in China
* Pharmaceutical industry in China
* Pharmacology
* Biotechnology
* Pharmaceutical marketing
* National pharmaceuticals policy
* Opium and Alkaloid Works
*


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