Radical retropubic prostatectomy

Radical retropubic prostatectomy is a surgical procedure in which the prostate gland is removed through an incision in the abdomen. It is most often used to treat individuals who have early prostate cancer. Radical retropubic prostatectomy can be performed under general, spinal, or epidural anesthesia and requires blood transfusion less than one-fifth of the time. Radical retropubic prostatectomy is associated with complications such as urinary incontinence and impotence, but these outcomes are related to a combination of individual patient anatomy, surgical technique, and the experience and skill of the surgeon.

Description

Radical retropubic prostatectomy was developed in 1945 by Terence Millin at the All Saints Hospital in London and was refined 1982 by [http://urology.jhu.edu/patrickwalsh/index.php Patrick C. Walsh ] at the James Buchanan Brady Urological Institute, Johns Hokpkins Medicine. [http://urology.jhu.edu/prostate/video1.php Radical retropubic prostatectomy] can be performed in several different ways with several possible associated procedures. The most common approach is to make an incision in the skin between the umbilicus and the top of the pubic bone. Since initial description by Walsh, technical advancements have been made, and incisional length has decreased to 8-10cm (well below the belt-line). The pelvis is then explored and the important structures such as the urinary bladder, prostate, urethra, blood vessels, and nerves are identified. The prostate is removed from the urethra below and the bladder above, and the bladder and urethra are reconnected. The blood vessels leading to and from the prostate are then divided and tied off. Recovery typically is rapid; individuals are usually able to walk and eat within 24 hours after surgery. A catheter through the penis into the bladder is typically required for at least a week after surgery. A surgical drain is often left in the pelvis for several days to allow drainage of blood and other fluid. Additional components of the operation may include:

* Lymphadenectomy - Prostate cancer often spreads to nearby lymph nodes in the early stages. Removal of select lymph nodes in the pelvis allows microscopic evaluation for evidence of cancer within these nodes. If cancer is found in the lymph nodes, different therapies may be offered
* Nerve-sparing surgery - Select individuals will be eligible for nerve-sparing surgery. Nerve-sparing surgery attempts to protect the Cavernous nerves of penis nerves which control erection. These nerves run next to the prostate and may be destroyed during surgery, leading to impotence. If the cancer is clinically unlikely to have spread beyond the prostate, nerve-sparing surgery should be offered to minimize impotency and to speed up urinary control. An inter-operative electrical stimulation penile plethysmograph may be applied to assist the surgeon in identifying the difficult to see nerves.

Indications

Radical retropubic prostatectomy is typically performed in men who have early stage prostate cancer. Early stage prostate cancer is confined to the prostate gland and has not yet spread beyond the prostate or to other parts of the body. Attempts are made prior to surgery, through medical tests such as bone scans, computed tomography (CT), and magnetic resonance imaging (MRI), to identify cancer outside of the prostate. Radical retropubic prostatectomy may also be used if prostate cancer has failed to respond to radiation therapy, but the risk of urinary incontinence is substantial.

Complications

The most common serious complications of radical retropubic prostatectomy are loss of urinary control and impotence. As many as forty percent of men undergoing prostatectomy may be left with some degree of urinary incontinence, usually in the form of leakage with sneezing, etc. (stress incontinence) but this is highly surgeon-dependent. Impotence is common when nerve-sparing techniques are not used. Although erection and ejaculation are affected, penile sensation and the ability to achieve orgasm remain intact. Therefore, use of medications such as sildenafil (Viagra), vardenafil (Levitra), or tadalafil (Cialis) may restore some degree of potency when the cavernous nerves remain functioning.

Continence and potency may improve depending on the amount of trauma and the patient's age at the time of the procedure, but progress is frequently slow. Potency is greatly affected by the psychological attitude of the patient. The sensation of orgasm may be altered and no semen is produced, but there may be a few drops of fluid from the bulbourethral glands. Marital counseling focusing on the changes may be effective in restoring potency or maintaining a satisfactory spousal relationship if impotence continues.

Erectile dysfunction outcomes can be predicted by intraoperative cavernous nerve electrical stimulation with a penile plethysmograph. [ Kolotz, L, et al. A Randomized Phase 3 Study Of Intraoperative Cavernous Nerve Stimulation with Penile Tumescence Monitoring to Improve Nerve Sparing During Radical Prostatectomy. "Journal of Urology" 2000;164(5):1573-1578. [http://www.jurology.com/article/S0022-5347(05)67031-0/abstract] ] The results aid in managing additional therapeutic options earlier.

References

Klein, EA, Jhaveri, F, Licht, M. "Contemporary technique of radical prostatectomy. In: Management of Prostate Cancer", Klein, EA (Ed), Humana Press, New Jersey, 2000

Millin T. Retropubic prostatectomy a new extravesical technique report, The Lancet 1945, Volume 246, Issue 6379, Pages 693-696.

Walsh PC, Donker PJ. Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 1982;128(3):492-497.