Antimycin A

Antimycin A

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ImageFile=Antimycin A.svg
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IUPACName= (2{R},3(S},6{S},7{R},8{R})-3- [(3-formamido-2-hydroxybenzoyl)amino] -8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate
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Section1= Chembox Identifiers
CASNo=642-15-9
PubChem=12550
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MeSHName=Antimycin+A
Section2= Chembox Properties
Formula=C28H40N2O9
MolarMass=548.625
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Antimycin A is a chemical compound produced by streptomyces bacteria.

Uses

It is the active ingredient in Fintrol, a chemical piscicide (fish poison) used in fisheries management and in the catfish industry.

It is also used as an antibiotic.

Mechanism

Antimycin A functions by inhibiting the oxidation of ubiquinol in the electron transport chain, ultimately preventing the formation of ATP.

More specifically, Antimycin A binds to the Qi site of Complex III (the enzyme cytochrome c oxidoreductase), in the cytochrome b subunit.

The inhibition of Complex III by Antimycin A result in the formation of large quantities of the toxic free radical, Superoxide.

It has also been found to inhibit the cyclic electron flow within photosynthetic systems along the proposed ferredoxin quinone reductase pathway.

Antimycin blocks the flow of electrons from semiquinone to ubiquinone in the Q-cycle of complex III in oxidative phosphorylation. By doing so it inhibits the electron transport pathway thus preventing the consumption of oxygen (which occurs at Complex IV) and disrupting the proton gradient across the inner membrane. It is the disruption of the proton gradient that prevents the production of ATP as protons are unable to flow through the ATP synthase complex.


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Look at other dictionaries:

  • antimycin — an ti*my cin ([a^]n t[i^]*m[imac] s[i^]n), n. 1. one of several antibiotic substances produced by several species of {Streptomyces}, active against various fungi. They are used only experimentally, not in medicine. The two best known antimycins… …   The Collaborative International Dictionary of English

  • Antimycin — steht für: Antimycin A, einen Hemmstoff des Komplex III der Atmungskette. Citrinin, ein Mykotoxin. Diese Seite ist eine Begriffsklärung zur Unterscheidung mehrerer mit demselben Wort bezeichneter Begriffe …   Deutsch Wikipedia

  • Antimycin A — Strukturformel Allgemeines Name Antimycin A1 Andere Namen …   Deutsch Wikipedia

  • antimycin A — noun Etymology: anti + mycin Date: 1949 a crystalline antibiotic C28H40N2O9 used especially as a fungicide, insecticide, and miticide called also antimycin …   New Collegiate Dictionary

  • antimycin — noun see antimycin A …   New Collegiate Dictionary

  • antimycin A — an·ti·my·cin A .ant i .mīs ən ā n a crystalline antibiotic C28H40N2O9 used esp. as a fungicide, insecticide, and miticide called also antimycin …   Medical dictionary

  • antimycin A — a chemical produced by streptomyces bacteria and used in a commercial preparation as a piscicide, e.g. in the catfish industry. It inhibits adenosine triphosphate (ATP) formation, the nucleotide necessary for transport of chemical energy within… …   Dictionary of ichthyology

  • antimycin — Inhibitor of QH2 cytochrome C reductase …   Dictionary of molecular biology

  • antimycin — noun Any of several lactone antibiotics, some of which are used for controlling fungi in fish farms …   Wiktionary

  • antimycin — an·ti·my·cin …   English syllables

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