Robinson-Gabriel synthesis

Robinson-Gabriel synthesis

The Robinson-Gabriel synthesis is a chemical reaction that forms oxazoles by dehydration of 2-acylamino-ketones.

Historically, the dehydration agent is concentrated sulfuric acid. Recently, phosphorus oxychloride is successful with this reaction also.

2-Acylamino-ketones can be synthesized using the Dakin-West reaction.

References

*Robinson, R. "J. Chem. Soc." 1909, "95", 2167.
*Gabriel, S. "Ber." 1910, "43", 134.
*Gabriel, S. "Ber." 1910, "43", 1283.


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