TSD

TSD may refer to:

* Tay-Sachs Disease, a genetic disorder, fatal in its most common variant
* Tang Soo Do (tangsudo), a Korean martial art that has been largely incorporated into modern Taekwondo
* Tell Show Do, a method of communication
* The Starship Destiny, a pixel art webcomic by Sean Howard
* TSD rally, a form of motor sport usually conducted on public roads that focuses on Time, Speed, and Distance calculations
* The Sickest Drama
* Technical SafeAir Diver
* CIA's Technical Services Division
* Telescope Systems Division
* temperature-dependent sex determination
* Texas School for the Deaf
* Text, Speech and Dialogue
* Tensai! Shimura Doubutsuen
* Thermal Shutdown
* thread-specific data
* Total Sleep Deprivation
* Training Systems Division
* Transient suppression device
* Transylvanian Society of Dracula
* Tivoli Service Desk
* Treasury Solicitor's Department
* Turtle Saving Devices, modified Turtle excluder devices
* Tyler Smith Disorder