- ALMANAC
ALMANAC is the name of a major
breast cancer trial. Theacronym stands for "Axillary Lymphatic Mapping Against Nodal Axillary Clearance." This majorrandomized trial performed in several centres in the UK produced clear evidence thatsentinel node biopsy (SNB), used to stage axillary spread of disease, can be used with low failed localization and false negative rates, provided bothradioisotope and blue dye are used to locate the sentinel nodes. [citebook|title=Sentinel Lymph Node Biopsy |author= Hiram S Cody,|year=2003|publisher=Informa Health Care|id=ISBN 1841840343|pages=237|url=http://books.google.com/books?id=gzE1STlawtUC&pg=PA237&ots=LRfU-laUCF&dq=%22Axillary+Lymphatic+Mapping+Against+Nodal+Axillary+Clearance%22&ie=ISO-8859-1&output=html&sig=IYwGmDfjzrhI02v65-djSogoe2g]Compared to standard axillary management, SNB results in greatly decreased arm problems and increased quality of life, without any increase in cancer-related anxiety. There is no evidence of a difference in local recurrence rates, though longer-term evidence on this is awaited from other studies.
References
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