Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate
Other names Phorbol dibutyrate; Phorbol 12,13-dibutanoate
Identifiers
Abbreviations	PDBu
CAS number	37558-16-0
PubChem	37783
Jmol-3D images	Image 1
SMILES CCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)CCC)O)C
Properties
Molecular formula	C28H40O8
Molar mass	504.61 g mol−1
Y 12,13-dibutyrate (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-Tetradecanoylphorbol-13-acetate.^[1]

PDBu is widely used as a chemical reagent because of its solubility in water and other organic solvents.

References

1. ^ Blumberg P M; Delclos K B; Dunn J A; Jaken S; Leach K L; Yeh E (1983). "Phorbol ester receptors and the in vitro effects of tumor promoters". Annals of the New York Academy of Sciences 407: 303–315. doi:10.1111/j.1749-6632.1983.tb47836.x. PMID 6309054.