Oso, or OSO, may refer to:
- Oso, California
- Oso, Ontario, a community Central Frontenac Township, Ontario, Canada
- Oso, Washington, a census-designated place in Snohomish County, Washington
- Oakville Symphony Orchestra
- Ose (demon)
- Onsala Space Observatory
- Orbiting Solar Observatory, series of nine satellites
- Ottawa Symphony Orchestra
- Om Shanti Om, Hindi film starring Shahrukh Khan, Deepika Padukone and Arjun Rampal
- Officer Selection Officer in the United States Marine Corps
- The Special Council of the NKVD; Russian "ОСО," transliterated "OSO."
- Special Agent Oso, a Disney Channel animated show for children.
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