Moniliformis moniliformis

Moniliformis moniliformis
Scientific classification
Kingdom:	Animalia
Phylum:	Acanthocephala
Class:	Archiacanthocephala
Order:	Moniliformida
Family:	Moniliformidae
Genus:	Moniliformis
Species:	M. moniliformis
Binomial name
Moniliformis moniliformis (Bremser, 1811)

Moniliformis moniliformis is a parasite of the Acanthocephala phylum in the family Moniliformidae. Along with Macrocanthorhynchus hirudinaceous, M. moniliformis is an acanthocephalan worm species that can infect humans, though rare.

The earliest known human infection was found in Utah in the coprolite of a prehistoric man. Specimen analysis showed a significant amount of M. moniliformis eggs in the coprolite.^[1] In 1888 in Italy, Calandruccio infected himself by ingesting larvae, reported gastrointestinal disturbances, and then shed the eggs in two weeks. This was the first report of the clinical manifestations of an M. moniliformis infection in humans.

Distribution

Infected rats have been found world-wide. Cases of human infection by Moniliformis moniliformis have been reported in the United States, Iran, Iraq, and Nigeria.^[2]

Morphology

Acanthocephalans do not have digestive tracts and absorb nutrients through the tegument, the external layer. The scolex of this worm has a cylindrical proboscis and a multitude of curved hooks. The main parts of the worm body are the proboscis, neck, and trunk. Because of horizontal markings on the worm, there is the appearance of segmentation. Acanthocephalans are sexually dimoprhic- adult males are generally 4 to 5 cm long while females are longer, ranging from lengths of 10 to 30 cm. Males also have copulatory bursas, used to hold on to the female during copulation and cement glands. Females have floating ovaries within a ligament sac where fertilization of the eggs occurs.^[3] The eggs of this parasite are 90-125 μm long and 65 μm wide. They are oval in shape with a thick, clear outer coat.^[4]

Reservoirs

While acanthocephalans rarely infect humans, there have been several cases reported of M. moniliformis causing acanthocephaliasis in humans as their definitive hosts. Usually, the definitive hosts for M. moniliformis are rodents, cats, dogs and red foxes (in Poland). The intermediate hosts are usually beetles and cockroaches.^[2][5]

Vectors

No known vectors

Life cycle

In the life cycle of M. moniliformis, the intermediate hosts ingest the eggs of the parasite. In the intermediate host, the acanthor, or the parasite in its first larval stage, morphs into the acanthella, the second larval stage. After 6–12 weeks in this stage, the acanthella becomes a cystacanth. The cystacanth, or infective acanthella, of M. moniliformis are cyst-shaped and encyst in the tissues of the intermediate hosts. However, most other acanthocephalans have infective larvae that more closely resemble underdeveloped adult worms. The definitive hosts consume the cystacanths upon feeding on infected intermediate hosts. These cystacanths mature and mate in the small intestine in 8–12 weeks. After this time, the eggs are excreted with the feces, to be ingested yet again by another intermediate host and renew this cycle.^[4]

Reproduction of the parasite only occurs in the definitive host. In acanthocephalans, adult males have cement glands in their posterior ends. The widely-held theory is that the mucilaginous and proteinaceous substance that these glands secrete are used by males use to seal up the females after copulation in order to prevent leakage of the inseminated sperm and further insemination by other males. It has also been found that these males may create this seal on other males in order to prevent them from copulating.^[6] These seals, or copulatory caps, last for a week.

Behavioral changes in the intermediate host

In what is commonly known as "brain-jacking," the parasite induces a behavioral change in its intermediate host that increases the risk of predation for the host. It is thought that this behavioral change holds an evolutionary advantage for the parasite by increasing its chances of getting to its definitive host. When Moniliformis moniliformis infects its intermediate host, the cockroach species, Periplaneta americana it changes the cockroach's escape response. In one study, it was concluded that cockroaches infected by M. moniliformis took longer to respond to wind stimuli simulating the approach of a potential predator and displayed fewer escape responses implying that the parasite infection renders its intermediate host more vulnerable to predation by hindering its ability to detect and escape from its predator. It is thought that serotonin plays a role in upending the communication between giant interneurons and the thoracic interneurons and in turn hampers the escape response of the cockroach.^[7] In a similar study, the effects of parasitism on 3 Periplaneta species are studied. The results show that Periplaneta australasiae uses substrates differently and moves around less when infected with Moniliformis moniliformis.^[8] Another study concludes an increased vulnerability of infected Periplaneta americana due to increased phototaxis, more time spent moving (due to slower movement) and movement in response to light (uninfected cockroaches hesitated before moving).^[9]

Human infection

Infection of a definitive host is called acanthocephaliasis. Because infection of humans would require human consumption of infected raw beetles or cockroaches, human acanthocephaliasis is rare.

Clinical manifestations

Calandruccio provided the first description of the clinical manifestations of acanthocephaliasis and similar accounts are found in the case studies since. There are not many case studies on acanthocephaliasis but of the ones that exist, many of the patients described were asymptomatic. When the patients exhibited symptoms, they normally experienced abdominal pain, diarrhea, dizziness, edema, and anorexia.^[10] In some patients, giddiness has also been reported.^[2] In rodents, acanthocephaliasis is fatal and manifests itself through similar hemorrhaging and gastrointestinal disturbance.

Diagnosis

The proper diagnosis of acanthocephaliasis in humans is made through fecal analysis, which if the host is infected should contain adult worms or eggs. To obtain the worms from the host, piperazine citrate, tetramisole and bithionol can be administered to the patient.^[10]

Treatment

Acanthocephaliasis is treated with anti-helminthics. There is considerable debate over the efficacy of anti-helminth drugs on this parasite, but thus far, the drugs seem to be working. Pyrantel pamoate has been shown to be particularly effective in treating patients, as has ivermectin.^[10] Mebendazole and thiabendazole have also both been cited to work.^[11][12]

Prevention strategies

Because the only way of developing acanthocephaliasis is through ingesting the intermediate hosts, the most effective means of prevention is avoiding the consumption of beetles and cockroaches. This is especially difficult in children exhibiting pica and in areas with poor hygiene. Awareness campaigns on the risks of consuming infected beetles and cockroaches would be effective. Moreover, preventing entry of the intermediate hosts into the home, and especially the kitchen where it is at risk of getting into the food, would help curb the risk of becoming infected.^[13]

References

1. ^ [1], Moore, JG, Fry, GF, Englert, EJR. Thorny-headed worm infection in North American prehistoric man. Science 1969; 1324–1325.
2. ^ ^{a b c} [2], "Acanthocephalan Worms." Gideon. Gideon Informatics. Web.
3. ^ [3], "Phylum: Acanthocephala." Lecture. Animal Parasitology. Kansas State, 14 March 2005. Web. 23 February 2010.
4. ^ ^{a b} [4], Acanthocephaliasis. Parasites and Health. CDC, 20 July 2009. Web.
5. ^ [5]
6. ^ Crompton, D.W.T. Reproduction. In Biology of the Acanthocephala (ed. Crompton, D. W. T. & Nickol, B. B.), pp. 213–271. Cambridge University Press, Cambridge. 1985
7. ^ [6] Libersat, F., and J. Moore. "The Parasite Moniliformis moniliformis Alters the Escape Response of its Cockroach Host Periplaneta americana." Journal of Insect Behavior 13.1 (2000): 103-10. Plenum Publishing. Web.
8. ^ [7], Moore, J., M. Freehling, and N. J. Gotelli. 1994. Altered behavior in two species of blattid cockroaches infected with Moniliformis moniliformis (Acanthocephala). Journal of Parasitology 80:220–223.
9. ^ [8], Moore, J. 1983. Altered behaviour in cockroaches (Periplaneta americana) infected with an archiacantho- cephalan Moniliformis moniliformis. J. Parasitol., 69, 1174-1177.
10. ^ ^{a b c} [9], Richardson, Dennis, and Peter J. Krause. Northern American parasitic zoonoses. Vol. 6. Boston: Kluwer Academic, 2003. Print.
11. ^ [10], Berenji, F., Fata, A., Hosseininejad, Z. A Case of Moniliformis Moniliformis (Acanthocephala) Infection in Iran. Korean Journal of Parasitology Vol. 45, No. 2: 145-148, June 2007
12. ^ [11], Salehabadi, Alireza; Mowlavi, Gholamreza; Sadjjadi, S.M., Vector-Borne and Zoonotic Diseases. February 2008, 8(1): 101-104.
13. ^ [12], Neafie, RC, Marty, AM. Unusual infections in humans. Clin Microbiol Rev 1993; 66:34–56.