Maytansinoid

A maytansinoid is a chemical derivative of maytansine.^[1]

Some are being investigated as the cytotoxic component of antibody-drug conjugates.^[1]

Examples:

• Ansamitocin^[2]
• Mertansine

References

1. ^ ^{a b} http://cancerres.aacrjournals.org/content/52/1/127.full.pdf
2. ^ http://www.pnas.org/content/99/12/7968.abstract

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Macrolides Experimental cancer drugs Pharmacology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Maytansine Mertansine Look at other dictionaries: maytansinoid DM4-conjugated humanized monoclonal antibody huC242 — A substance being studied in the treatment of some types of cancer. It is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid DM4. The monoclonal antibody locates and binds to the surfaces of cancer cells and… …   English dictionary of cancer terms Maytansinoide — Die Strukturformel von Maytansin. Maytansinoide ist der Name für eine Gruppe von Naturstoffen, mit hoher zytotoxischer Wirkung. Die Maytansinoide wurden erstmals 1972 aus dem in Äthiopien beheimateten Strauch Maytenus serrata isoliert.… …   Deutsch Wikipedia huC242-DM4 — A substance being studied in the treatment of some types of cancer. It is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid DM4. The monoclonal antibody locates and binds to the surfaces of cancer cells and… …   English dictionary of cancer terms Mertansine — Other names Maytansinoid DM1 N2 deacetyl N2 (3 mercapto 1 oxopropyl) maytansine …   Wikipedia Chemoimmunkonjugat — Ein Chemoimmunkonjugat, engl. Chemoimmunoconjugate, ist ein Immunkonjugat, das aus einer zellbindenden Komponente und einem Zytostatikum besteht. Chemoimmunkonjugate sind potenzielle Arzneistoffe, die vor allem in der Onkologie zur Behandlung von …   Deutsch Wikipedia Maytansine — Other names Maytansin Identifiers …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”