DmpG-like communication domain

DmpG-like communication domain
crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate
Identifiers
Symbol	DmpG_comm
Pfam	PF07836
InterPro	IPR012425
SCOP	1nvm
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

In molecular biology, the DmpG-like communication domain is a protein domain found towards the C-terminal region of various aldolase enzymes. It consists of five alpha-helices, four of which form an antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain.^[1] The communication domain is thought to play an important role in the heterodimerisation of the enzyme.^[1]

This domain heterodimerises with acetaldehyde dehydrogenases to form a bifunctional aldolase-dehydrogenase.^[1]

References

1. ^ ^{a b c} Manjasetty BA, Powlowski J, Vrielink A (June 2003). "Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate". Proc. Natl. Acad. Sci. U.S.A. 100 (12): 6992–7. doi:10.1073/pnas.1236794100. PMC 165818. PMID 12764229. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165818. 

This article includes text from the public domain Pfam and InterPro IPR012425