Dalfopristin

Dalfopristin

Systematic (IUPAC) name
(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a- octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]-dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a603007
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Half-life	1 hour
Identifiers
CAS number	112362-50-2 Y
ATC code	None
PubChem	CID 6435782
DrugBank	DB01764
ChemSpider	4940480 N
UNII	R9M4FJE48E N
KEGG	D00853 N
ChEMBL	CHEMBL1200937 N
Chemical data
Formula	C34H50N4O9S
Mol. mass	690.85 g/mol
N(what is this?)  (verify)

Dalfopristin is a streptogramin antibiotic derived from pristinamycin IIA. The combination quinupristin/dalfopristin, in a weight-to-weight ratio of 30% quinupristin to 70% dalfopristin, is used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.^[1]

References

1. ^ Allington DR, Rivey MP (2001). "Quinupristin/dalfopristin: a therapeutic review". Clin Ther 23 (1): 24–44. doi:10.1016/S0149-2918(01)80028-X. PMID 11219478. 

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Pharmacology stubs Antibiotics Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Daleyville, Wisconsin Dalfsen railway station Look at other dictionaries: dalfopristin — noun A streptogramin antibiotic derived from pristinamycin …   Wiktionary dalfopristin — dal·fo·pris·tin (dal foґpris tin) a semisynthetic streptogramin antibacterial effective against a variety of gram positive organisms, inhibiting the early phase of protein synthesis in the bacterial ribosome. It is used in conjunction with… …   Medical dictionary Quinupristin/dalfopristin — drugbox IUPAC name = Quinupristin: N [(6 R ,9 S ,10 R ,13 S ,15a S ,18 R ,22 S ,24a S ) 22 [p (dimethylamino)benzyl] 6 ethyldocosahydro 10,23 dimethyl 5,8,12,15,17,21,24 heptaoxo 13 phenyl 18 [(3 S ) 3 quinuclidinylthio] methyl] 12 H pyrido [2,1… …   Wikipedia Streptogramin — Streptogramine bezeichnen eine Klasse an Antibiotika, die sich allesamt von Pristinamycin, einem Stoffwechselprodukt des Bakteriums Streptomyces pristinae spiralis ableiten. Ihnen ist gemein, dass sie die Proteinbiosynthese von Bakterien hemmen… …   Deutsch Wikipedia Streptogramine — bezeichnen eine Klasse von Antibiotika, die sich allesamt von Pristinamycin, einem Stoffwechselprodukt des Bakteriums Streptomyces pristinae spiralis ableiten. Ihnen ist gemein, dass sie die Proteinbiosynthese von Bakterien hemmen und so deren… …   Deutsch Wikipedia Streptogramin — Streptogramins are a class of antibiotics. They are a combination of Quinupristin and dalfopristin in a 30:70 ratio. Streptogramins are bactericidal. This class of antibiotics inhibit protein synthesis in a synergestic manner. Quinupristin binds… …   Wikipedia Enterococcus — Taxobox color = lightgrey name = Enterococcus image width = 240px image caption = Enterococcus sp. infection in pulmonary tissue. regnum = Bacteria divisio = Firmicutes classis = Bacilli ordo = Lactobacillales familia = Enterococcaceae genus =… …   Wikipedia Vancomycin-resistant Staphylococcus aureus — (VRSA) is a strain of Staphylococcus aureus that has become resistant to the glycopeptide antibiotic vancomycin. With the increase of staphylococcal resistance to methicillin, vancomycin (or teicoplanin) is often a treatment of choice in… …   Wikipedia Pristinamycin — drugbox IUPAC name = CAS number = ATC prefix = J01 ATC suffix = FG01 PubChem = DrugBank = chemical formula = molecular weight = bioavailability = protein bound = metabolism = elimination half life = excretion = pregnancy AU = pregnancy US =… …   Wikipedia Линезолид — …   Википедия 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”