TRIM62

TRIM62

TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1),[1] is a protein in the tripartite motif family. In human it is encoded by the gene TRIM62.[2] TRIM62 is involved in the morphogenesis of the mammary gland, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer.[1]

References

  1. ^ a b Lott ST, Chen N, Chandler DS, Yang Q, Wang L, et al. (2009). Minna, John D.. ed. "DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer". PLoS Medicine 6 (5): e1000068. doi:10.1371/journal.pmed.1000068. PMC 2673042. PMID 19536326. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000068. 
  2. ^ "TRIM62 tripartite motif-containing 62 [ Homo sapiens ]". Entrez Gene. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55223&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum. Retrieved 1 Jun 2009. 
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