Cramp fasciculation syndrome

Cramp fasciculation syndrome

Cramp fasciculation syndrome is a rare[1] peripheral nerve hyperexcitability disorder. It is more severe than the related and common disorder known as benign fasciculation syndrome, causing fasciculations, cramps, pain, fatigue, and muscle stiffness similar to those seen in neuromyotonia, another related condition.[2] Patients with CFS, like those with neuromyotonia, may also experience paresthesias.[3]

Most cases of cramp fasciculation syndrome are idiopathic.[4]

Cramp fasciculation syndrome is diagnosed by clinical examination and electromyographic study (EMG).[5] Fasciculation is the only abnormality,[6] if any,[7] seen with EMG.

Cramp fasciculation syndrome is a chronic condition.[8] Treatment options include anti-seizure medications such as carbamazepine, as well as immunosuppressant medications and plasmapheresis.[9]

References

  1. ^ Jansen, P. H. P.; Dijck, J. A. A. M.; Verbeek, A. L. M.; Durian, F. W.; Joosten, E. M. G. (1991). "Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population". European Archives of Psychiatry and Clinical Neuroscience 241 (2): 102–4. doi:10.1007/BF02191150. PMID 1834178. 
  2. ^ Ropper, Allan H.; Brown, Robert H. (2005). "Disorders of Muscle Characterized by Cramp, Spasm, Pain, and Localized Masses". Adams and Victor's Principles of Neurology (8th ed.). New York: McGraw-Hill. pp. 1277–8. ISBN 978-0-07-141620-7. 
  3. ^ Hart, Ian K.; Maddison, Paul; Newsom‐Davis, John; Vincent, Angela; Mills, Kerry R. (2002). "Phenotypic variants of autoimmune peripheral nerve hyperexcitability". Brain 125 (8): 1887–95. doi:10.1093/brain/awf178. PMID 12135978. 
  4. ^ Lagueny, A (2005). "Cramp-fasciculation syndrome". Revue neurologique 161 (12 Pt 1): 1260–6. PMID 16340924. 
  5. ^ Washington University in St. Louis, Neuromuscular: Cramp-Fasciculation Syndromes, http://neuromuscular.wustl.edu/mother/activity.html#crampfas
  6. ^ Tahmoush, AJ; Alonso, RJ; Tahmoush, GP; Heiman-Patterson, TD (1991). "Cramp-fasciculation syndrome: a treatable hyperexcitable peripheral nerve disorder". Neurology 41 (7): 1021–4. PMID 1648679. 
  7. ^ TeleEMG website, Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease, Page 2 http://www.teleemg.com/new/als2.htm
  8. ^ de Entrambasaguas, Manuel; Ortega-Albás, Juan-José; Martínez-Lozano, María-Dolores; Díaz, José-Ramón (2006). "Bronchial involvement in the cramp-fasciculation syndrome". European neurology 56 (2): 124–6. doi:10.1159/000095703. PMID 16960453. 
  9. ^ Lagueny, A (2005). "Cramp-fasciculation syndrome". Revue neurologique 161 (12 Pt 1): 1260–6. PMID 16340924. 

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