Complete Genomics

Complete Genomics is a life sciences company that has developed and commercialized a DNA sequencing platform for human genome sequencing and analysis. This solution combines the company’s proprietary human genome sequencing technology with its informatics and data management software in an outsourced service model that provides its customers with finished variant reports and assemblies. Researchers send DNA samples to the company, which are sequenced at Complete Genomics’ own commercial genome center in Mountain View, California. Sequencing is completed using the company’s proprietary instruments and technology. Assembled sequences and variant reports are then delivered back to the researcher.

History

Complete Genomics was founded in March 2006 by Clifford Reid, Radoje (Rade) Drmanac, and John Curson. Clifford Reid is the chairman, president and chief executive officer of Complete Genomics.

In Feb. 2009, Complete Genomics announced that it had sequenced its first human genome and submitted the resulting variant data to the National Center for Biotechnology Information database. Then in Nov. 2009, Complete Genomics published sequence data for three human genomes in the journal Science.[1] By the end of that year, Complete Genomics had sequenced 50 human genomes. The company has now significantly increased the throughput in its genome sequencing factory; it sequenced and analyzed 300 complete human genomes in Q3 2010.

In addition, Complete Genomics’ customers are now publishing papers describing research completed using data from Complete Genomics. Examples include the Institute for Systems Biology’s project to sequence a family of four and verify the gene responsible for Miller Syndrome, a rare craniofacial disorder[2] and Genentech’s work to sequence and compare a patient’s primary lung tumor and adjacent normal tissue [3].

Technology Platform

Complete Genomics’ proprietary human genome sequencing technology is optimized for the exclusive study of human DNA, providing assembled sequences and variation files. The technology relies on DNA nanoball sequencing. It is designed to use lower volumes and concentrations of reagents than existing systems. Additionally, Complete Genomics’ proprietary instrumentation allows for greater numbers of base reads per image.[1]

References

1. Drmanac R et al. (November 2009). "Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays.". Science 327 (5961): 78–81. doi:10.1126/science.1181498. PMID 19892942. http://www.sciencemag.org/cgi/content/abstract/1181498?ijkey=2cSK/YvTtuDSU&keytype=ref&siteid=sci.
2. Roach et al. Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing. Science 30 April 2010 328: 636-639; published online 10 March 2010.
3. Lee et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature 465, 473-477 (27 May 2010) | doi:10.1038/nature09004; Received 7 December 2009; Accepted 10 March 2010.

External links

• Official Website

This article about a medical, pharmaceutical or biotechnological corporation or company is a stub. You can help Wikipedia by expanding it.v · Categories: Biotechnology companies Companies established in 2006 Genomics companies Medical company stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Complete Failure (band) Complete Greatest Hits (The Cars album) Look at other dictionaries: Genomics — This article is about the scientific field. For the journal, see Genomics (journal). Genomics is a discipline in genetics concerning the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence… …   Wikipedia genomics — /jee noh miks, nom iks/, n. (used with a singular v.) the study of genomes. [1985 90] * * * Introduction  study of the structure, function, and inheritance of the genome (entire set of genetic material) of an organism. A major part of genomics is …   Universalium genomics — noun plural but singular in construction Date: 1987 a branch of biotechnology concerned with applying the techniques of genetics and molecular biology to the genetic mapping and DNA sequencing of sets of genes or the complete genomes of selected… …   New Collegiate Dictionary genomics — noun The study of the complete genome of an organism …   Wiktionary genomics — Study of the structure of the genome of particular organisms, including mapping and sequencing. functional g. the study of expressed genes in organisms, including the identity of the genes and the factors that control differential expres …   Medical dictionary genomics — The study of the complete genetic material, including genes and their functions, of an organism …   English dictionary of cancer terms Computational genomics — refers to the use of computational analysis to decipher biology from genome sequences and related data [1], including both DNA and RNA sequence as well as other post genomic data (i.e. experimental data obtained with technologies that require the …   Wikipedia The Centre for Applied Genomics — Infobox Company name = The Centre for Applied Genomics type = Genome Centre foundation = 1998 location city = Toronto location country = Canada location = locations = key people = [http://www.tcag.ca/scherer/ Dr. Stephen W. Scherer] , Scientific… …   Wikipedia functional genomics — The field of research, that aims to determine patterns of gene expression and interaction in the genome, based on the knowledge of extensive or complete genomic sequence of an organism …   Glossary of Biotechnology Full genome sequencing — Genome sequencing redirects here. For the sequencing only of DNA, see DNA sequencing. An image of the 46 chromosomes, making up the diploid genome of human male. (The mitochondrial chromosome is not shown.) Full genome sequencing (FGS), also… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”