Bovine enterovirus

Bovine enterovirus

Taxobox | color=violet
name = "Bovine enterovirus"
image_caption =
Bovine Enterovirus.



virus_group = iv
familia = "Picornaviridae"
genus = "Enterovirus"
species = Bovine enterovirus

Bovine enterovirus (BEV) is a picornavirus of the genus enterovirus. It is endemic in cattle populations but is non-pathogenic. BEV has a non-enveloped, icosahedral protein capsid composed of four structural proteins, VP1, VP2, VP3 and VP4. The capsid has a diameter of 27nm and encloses a single stranded positive sense RNA genome of approximately 7500 bases.

Occurrence

The bovine enteroviruses are endemic in cattle populations worldwide. BEVs were originally classified into seven serotypes but are now accepted as falling into two serotypes, 1 and 2, which are further classified into subtypes. BEV strain VG-5-27 of serotype 1, subtype 1 is the most extensively studied. The tissue tropism of BEV is extremely broad, including human, sheep, horse, dog, camel and other mammalian hosts. BEV-like sequences have even been reported in shellfish from water contaminated with bovine faeces.

Structure

In common with other picornaviruses, the capsid of BEV is composed of 60 copies of each of four structural proteins, VP1, VP2, VP3 and VP4, in icosahedral symmetry. The capsid is non-enveloped and roughly spherical with an outer radius of 159 Ångström and an inner radius of 107 Ångström. The outer surface of BEV is smoother than the closely related poliovirus due to the truncation of surface protein loops in BEV. It is also smoother than the related human rhinovirus due to the extension of a surface loop in BEV. The three antigenic sites of BEV all occur on a surface ridge at the junction between VP1, VP2 and VP3. BEV has a crater-like depression at the icosahedral 5-fold axis which descends into a cylindrical hole of 10 Ångström in diameter which runs almost to the inner suface of the capsid. A hydrophobic pocket contained within VP1 contains a myristic acid molecule, the removal of which appears to be a pre-requisite for virus uncoating.

Replication

Cloning

References

Smyth M, Pettitt T, Symonds A and Martin J (2003) Identification of the Pocket Factors in a Picornavirus.Archives Virol 148: 1225-33.

Smyth MS, Symonds A, Brazinova S and Martin JHJ (2002) Bovine Enterovirus as an Oncolytic Virus: Foetal Calf Serum Facilitates its infection of Human Cells. Int. J. Mol. Med. 10, 49-53

Smyth, M.S. and Martin, JHJ (2002)Picornavirus Uncoating. J Clin Path; Mol Path 55: 214-219

Smyth, M.S. & Martin, J.H.J. (2001)Structural, biochemical and electrostatic basis of serotype specificity in bovine enteroviruses. Archives Virol. 146, 347-355

Smyth, M., Trudgett, A., Martin, J., Hoey, E. and Martin S. (2000) Conformational changes during proteolytic processing of picornavirus capsid proteins. Archives Virol. 145, 1473-1479

Smyth M, Tate J, Hoey E, Lyons C, Martin S, Stuart D. Implications for viral uncoating from the structure of bovine enterovirus. Nat Struct Biol. 1995 Mar;2(3):224-31.

Smyth M, Fry E, Stuart D, Lyons C, Hoey E, Martin SJ Preliminary crystallographic analysis of bovine enterovirus. J Mol Biol. 1993 Jun 5;231(3):930-2.

Smyth MS, Trudgett A, Hoey EM, Martin SJ, Brown F. Characterization of neutralizing antibodies to bovine enterovirus elicited by synthetic peptides. Arch Virol. 1992;126(1-4):21-33.

Smyth MS, Hoey EM, Trudgett A, Martin SJ, Brown F. Chemically synthesized peptides elicit neutralizing antibody to bovine enterovirus. J Gen Virol. 1990 Jan;71 ( Pt 1):231-4.


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • bovine enterovirus — a species of the genus Enterovirus, separable into two serotypes, that have been associated with infertility and abortion in cattle …   Medical dictionary

  • Enterovirus — ] For example, both bovine and human lactoferrins were found to be potent inhibitors of EV71 infection and ribavirin could be a potential anti EV71 drug. [cite journal |author=Li ZH, Li CM, Ling P, et al |title=Ribavirin reduces mortality in… …   Wikipedia

  • BEV — baboon endogenous virus; beam s eye view; Berne virus; bovine enterovirus * * * Bev billion electron volts; the term is now largely replaced by the term gigaelectron volt (GeV) …   Medical dictionary

  • BEV — • baboon endogenous virus; • beam s eye view; • Berne virus; • bovine enterovirus …   Dictionary of medical acronyms & abbreviations

  • BEV — dairy abbr. Bovine Enterovirus …   United dictionary of abbreviations and acronyms

  • EV-71 — Enterovirus 71 (EV71) EV71 was first isolated and characterized from cases of neurological disease in California in 1969. [http://jcm.asm.org/cgi/reprint/40/1/10.pdf Change of Major Genotype of Enterovirus 71 in Outbreaks of Hand Foot and Mouth… …   Wikipedia

  • Virus — A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with… …   Medical dictionary

  • List of viruses — This is a list of biological viruses. See also List of computer viruses This is a list of biological viruses, and types of viruses. Please add to this list as appropriate. Note that some of these terms may be synonyms for the same virus; if there …   Wikipedia

  • Health and Disease — ▪ 2009 Introduction Food and Drug Safety.       In 2008 the contamination of infant formula and related dairy products with melamine in China led to widespread health problems in children, including urinary problems and possible renal tube… …   Universalium

  • Disease — Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”