34βE12

34βE12

34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14. [cite journal |author=Aishima S, Asayama Y, Taguchi K, "et al" |title=The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma |journal=Mod. Pathol. |volume=15 |issue=11 |pages=1181–90 |year=2002 |month=November |pmid=12429797 |doi=10.1097/01.MP.0000032537.82380.69 |url=http://www.nature.com/modpathol/journal/v15/n11/full/3880675a.html] cite journal |author=Yeh IT, Mies C |title=Application of immunohistochemistry to breast lesions |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=349–58 |year=2008 |month=March |pmid=18318578 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=349]

It is sometimes, less precisely, referred to as high-molecular weight keratin (HMWK) and high-molecular weight cytokeratin (HMWCK).

Utility

It is used to stain basal cells in prostatic glands; loss of basal cells is seen in prostate adenocarcinoma (the most common form of prostate cancer).

It can be used to differentiate "in situ" cancers of the breast; "lobular carcinoma in situ" (LCIS) exhibits perinuclear staining with 34βE12. Ductal carcinoma in situ (DCIS) does not stain for 34βE12.

ee also

*Immunohistochemistry

References


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