Long range RNA cis-elements in WNV

Long range RNA cis-elements in WNV (West Nile virus) are involved in virus replication. There are two proposed long-range RNA interactions, both mediated by nucleotide base-pairing, which cause in genome cyclization. The first interaction is between a 5'CS element (a conserved sequence located in the N-terminal region of the C gene) and a 3'CSI element (located at the 3' UTR). The second interaction is between a 5′UAR (upstream initiation AUG region) element and a 3′UAR sequence (located at the 3′ of the genome)cite journal |author=Dong H, Zhang B, Shi PY |title=Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein |journal=Virology |volume= |issue= |pages= |year=2008 |month=September |pmid=18799181 |doi=10.1016/j.virol.2008.07.040 |url=http://linkinghub.elsevier.com/retrieve/pii/S0042-6822(08)00508-4] .The second long-range interaction is reported to be essential for replication of the WNVcite journal |author=Alvarez DE, Filomatori CV, Gamarnik AV |title=Functional analysis of dengue virus cyclization sequences located at the 5' and 3'UTRs |journal=Virology |volume=375 |issue=1 |pages=223–35 |year=2008 |month=May |pmid=18289628 |doi=10.1016/j.virol.2008.01.014 |url=http://linkinghub.elsevier.com/retrieve/pii/S0042-6822(08)00040-8] .

Also see

*Cis-regulatory element

References