Tandem chimerism

Tandem chimerism

Tandem chimerism is the phenomenon where two consecutive genes are transcribed into a single RNA molecule [Parra et al., Tandem chimerism as a means to increase protein complexity in the human genome, Genome Research, 2006 PubMed|16344564] . The translation (after splicing) of such RNAs can lead to a new, fused protein, having parts from both original proteins. [Bone Marrow and Stem Cell Transplantation: NOD2/CARD15 / Julia Brenmoehl, ErnstHoller, and Gerhard Rogler] [Role of natural killer cells and killer immunoglobulin-like receptor polymorphisms: association of HLA and KIRs / M. Tevfik Dorak] [Identification of bone marrow derived nonhematopoietic cells ... by Meral Beksac, Contributor Meral Beksac, Published by Humana Press, 2007 ISBN 1588295958, ISBN 9781588295958]

External links

* [http://www.ncbi.nlm.nih.gov/pubmed/16344564 "Parra et al, Tandem Chimerism as a means to increase protein complexity in the human genome"]

References

* Akiva et al., "Transcription-mediated gene fusion in the human genome", Genome Research, 2006


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