Rs1800955

Infobox Single nucleotide polymorphism
rsid = 1800955
name_1 = C-521T
name_2 = -521C/T
gene = DRD4
region = Promotor
alfred = SI000215I
szgene_geneid = 94
szgene_polyid = 801In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP).It is located in the promotor region of the "DRD4" gene.This gene codes for the dopamine receptor D4.

Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder. [Cite web
url = http://www.schizophreniaforum.org/res/sczgene/meta.asp?geneID=94&polyID=801
publisher = Schizophrenia Research Forum
title = Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs1800955
accessdate = 2008-09-05]

The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory. [Cite journal
author = Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe & T. Arinami
title = Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait
journal = Molecular Psychiatry
volume = 5
issue = 1
pages = 64–69
year = 2000
month = January
pmid = 10673770] [Cite journal
author = Z. Ronai, A. Szekely, Z. Nemoda, K. Lakatos, J. Gervai, M. Staub & M. Sasvari-Szekely
title = Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene
journal = Molecular Psychiatry
volume = 6
issue = 1
pages = 35–38
year = 2001
month = January
pmid = 11244482] A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small. [Cite journal
author = Marcus R. Munafo, Binnaz Yalcin, Saffron A. Willis-Owen & Jonathan Flint
title = Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
journal = Biological Psychiatry
volume = 63
issue = 2
pages = 197–196
year = 2008
month = January
doi = 10.1016/j.biopsych.2007.04.006
pmid = 17574217]

Reference

Other

* [http://www.nature.com/mp/journal/v11/n10/fig_tab/4001869t4.html Table 4] from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"