Pemirolast

Drugbox
IUPAC_name = 9-methyl-3-(2H-tetrazol-5-yl)pyrido [2,1-b] pyrimidin-4-one

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CAS_number = 69372-19-6
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PubChem = 57697
DrugBank =
chemical_formula =
C=10 | H=8 | N=6 | O=1
molecular_weight = 228.21 g/mol
smiles = CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3
bioavailability =
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pregnancy_AU =
pregnancy_US = C
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legal_status = Rx-only
routes_of_administration = Oral, ophthalmic

Pemirolast (INN) is an anti-allergic drug. It is marketed under the tradenames Alegysal and Alamast.

It has also been studied for the treatment of asthma.

References

*cite journal |author=Tinkelman DG, Berkowitz RB |title=A pilot study of pemirolast in patients with seasonal allergic rhinitis |journal=Ann Allergy |volume=66 |issue=2 |pages=162–5 |year=1991 |month=February |pmid=1994787 |doi= |url=
*cite journal |author=Kawashima T, Iwamoto I, Nakagawa N, Tomioka H, Yoshida S |title=Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils |journal=Int. Arch. Allergy Immunol. |volume=103 |issue=4 |pages=405–9 |year=1994 |pmid=8130655 |doi= |url=
*cite journal |author=Abelson MB, Berdy GJ, Mundorf T, Amdahl LD, Graves AL |title=Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies |journal=J Ocul Pharmacol Ther |volume=18 |issue=5 |pages=475–88 |year=2002 |month=October |pmid=12419098 |doi=10.1089/10807680260362759 |url=
*cite journal |author=Kemp JP, Bernstein IL, Bierman CW, "et al" |title=Pemirolast, a new oral nonbronchodilator drug for chronic asthma |journal=Ann Allergy |volume=68 |issue=6 |pages=488–91 |year=1992 |month=June |pmid=1610024 |doi= |url=

External links

*cite web | author = Mitsubishi Tanabe Pharma Corporation | year = 2007 | url = http://www.e-search.ne.jp/~jpr/PDF/MITSUB32.PDF | title = ALEGYSAL® (English) | accessdate = 2008-09-02
*cite web | author = VISTAKON® Pharmaceuticals, LLC | year = 2005 | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=3230 | title = ALAMAST® (pemirolast potassium opthalmic solution) 0.1% | accessdate = 2008-09-02