Nenitzescu indole synthesis

Nenitzescu indole synthesis

The Nenitzescu indole synthesis is a chemical reaction that forms 5-hydroxyindole derivatives from benzoquinone and β-aminocrotonic esters.

The Nenitzescu indole synthesis

References

  • Nenitzescu, C. D. Bull. Soc. Chim. Romania 1929, 11, 37.
  • Allen, Jr., G. R. et al. J. Am. Chem. Soc. 1966, 88(11), 2536-2544. (PMID: 5941382)
  • Allen, Jr., G. R. Org. React. 1973, 20, 337.
  • Pawlak, J. M. et al. J. Org. Chem. 1996, 61, 9055.