Living Human Project

Living Human Project

The Living Human Project (LHP) is developing a worldwide, distributed repository of anatomo-functional data and of simulation algorithms relative to the human musculoskeletal apparatus, fully integrated into a seamless simulation environment and directly accessible by any researcher in the world. This infrastructure will be used to create the physiome of the human musculoskeletal system.

The Story so far

This initiative started in 2002 as a result of the BioNet coordination action, aimed to establish the grand challenges for European biomechanics. The [http://www.biomedtown.org/biomed_town/LHDL/Reception/lhp-public-repository/BioNet_WG_B_consensus.pdf BioNet consensus document] clearly pointed out the need for an Internet-based virtual community as a mean to share biomechanics data.

In 2003 a group of partners who were also involved with the BioNet action wrote a [http://www.biomedtown.org/biomed_town/LHDL/Reception/lhp-public-repository/LHP_global_plan_R3.pdf public document] drafting a possible strategy to have the LHP started.

In the meanwhile Marco Viceconti, a researcher at the [http://www.ior.it/tecno/ Rizzoli Institute] in Bologna (Italy) started a voluntary effort called Biomechanics European Lab (BEL). The idea was to create a community of interested colleagues, who would develop the LHP without any centralised funding.

In 2006 The BEL was merged with to [http://www.biomedtown.org Biomed Town] , a new Internet community reserved to all those who have professional interest in biomedical research. The [http://www.biomedtown.org/biomed_town/LHDL/Reception/datarepository BEL data repository] remains available on Biomed Town for historical reasons.

It was evident that the most important limiting factor for LHP was the lack of an adequate information technology infrastructure. This need is now being matched by two separate provisions.

Living Human Digital Library

A [http://www.biomedtown.org/biomed_town/LHDL/Reception/lhpdef/LHDLConsortium consortium of European institutions] is developing the [http://www.biomedtown.org/biomed_town/LHDL/Reception/lhpdef/LivingHumanDigitalLibrary Living Human Digital Library] , as part of the [http://www.biomedtown.org/biomed_town/LHDL/Reception/lhpdef/LHDLResearchProject LHDL STRP project] supported by the European Commission. This [http://www.biomedtown.org/biomed_town/LHDL/Reception/lhpdef/LivingHumanDigitalLibrary wiki page] contains constantly updated information on the LHDL project.

The LHDL project will end on January 2009; soon after the LHDL consortium will release a biomedical data management & sharing service, called Physiome Space. Physiome Space will make possible for single researchers as well as for large consortia to share with their peers very large collections of biomedical data, including medical imaging, computer simulations, etc. It is possible to sign-up for the [http://www.biomedtown.org/biomed_town/LHDL/Reception/betauser/ beta users group] , which should start in the last quarter of 2008.

Biomed Town

The users of LHP, e.g. all those research, industry, or clinical professionals that are interested in the musculoskeletal system in every possible way and at every dimensional scale, from the whole body down to the cell and the proteins, created a collaborative community within Biomed Town. The activities of the LHDL Consortium are hosted in the [http://www.biomedtown.org/biomed_town/LHDL/ LHDL Building] . The community consensus process takes place in the [http://www.biomedtown.org/biomed_town/lhpsquare/ Living Human Square] .

See also

* List of omics topics in biology
* Virtual Physiological Human
* Physiomics
* Physiome
* Physiology
* EuroPhysiome
* Human anatomy

External links

* [http://www.biomedtown.org/join_form Apply to become a Biomed Town citizen]
* [http://www.livinghuman.org LHDL - The Living Human Digital Library]
* [http://www.physiome.org/Links/ Physiome] - Links
* [http://www.physiome.ox.ac.uk/ Wellcome Trust Heart Physiome Project] - Links
* [http://www.europhysiome.org Strategy for the European Physiome] - (STEP)
* [http://www.physiome.org/ NSR Physiome Project]
* [http://www.physiome.org.nz/ IUPS Physiome Project]

References

* Viceconti, M., Taddei, F., Petrone, M., Galizia, S., Jan, S. V. S., and Clapworthy, G., 2006, "Towards the Virtual Physiological Human: the Living Human Project," The 7th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE 2006), Antibes Cote d’Azur, France.

* Viceconti, M., Taddei, F., Montanari, L., Testi, D., Leardini, A., Clapworthy, G., and Van Sint Jan, S., 2007, "Multimod Data Manager: A tool for data fusion," Computer Methods and Programs in Biomedicine, 87(2), pp. 148-159.

* Viceconti, M., Taddei, F., Van Sint Jan, S., Leardini, A., Clapworthy, G., Galizia, S., and Quadrani, P., 2007, "Towards the multiscale modelling of musculoskeletal system," Bioengineering Modeling and Computer Simulation, Barcelona, Spain.

* Viceconti, M., Zannoni, C., Testi, D., Petrone, M., Perticoni, S., Quadrani, P., Taddei, F., Imboden, S., and Clapworthy, G., 2007, "The multimod application framework: A rapid application development tool for computer aided medicine," Computer Methods and Programs in Biomedicine, 85(2), pp. 138-151.

* Viceconti, M., Taddei, F., Van Sint Jan, S., Leardini, A., Cristofolini, L., Stea, S., Baruffaldi, F., and Baleani, M., 2008, "Multiscale modelling of the skeleton for the prediction of the risk of fracture," Clinical biomechanics (Bristol, Avon).

* Zhao, X., Liu, E., and Clapworthy, G., 2008, "Service-Oriented Digital Libraries: A Web Services Approach," Internet and Web Applications and Services, 2008. ICIW'08. Third International Conference on, pp. 608-613.


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