HLA-B15

HLA-B15 (B15) is an HLA-B serotype. The serotype identifies the B*15 gene-allele protein products of HLA-B.cite journal | author = Marsh SG, Albert ED, Bodmer WF, "et al" | title = Nomenclature for factors of the HLA system, 2004 | journal = Tissue Antigens | volume = 65 | issue = 4 | pages = 301–69 | year = 2005 | pmid = 15787720 | doi = 10.1111/j.1399-0039.2005.00379.x]

B15 is a can be subdivided into several s that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77. B*15 is the largest allele grouping for any known human autosomal locus, idenitified as of August 2008 there are more than 150 alleles and ~140 amino acid sequence variants from those gene products. Some of these alleles are discussed below. Other alleles, such as B*46 evolved from B*15. One reason for the diversity of this group is that B15 is among a group of alleles enriched in the original humans that left Africa and dispersed across East Asia and Australia. As people traveled east the frequency of many alleles dropped or disappeared from migrants. However B*15 persisted, expanded and diversified.cite journal |author=Hildebrand WH, Domena JD, Shen SY, "et al" |title=HLA-B15: a widespread and diverse family of HLA-B alleles |journal=Tissue Antigens |volume=43 |issue=4 |pages=209–18 |year=1994 |month=April |pmid=7521976 |doi= |url=] The wide range and complex environment selected for new alleles and promoted their expansion. B*46 for example is not found in Africa, and appears to have evolved and spread in East Asia, to several 100 million bearers worldwide.

HLA-B15 allele *1502 is associated with severe skin condition caused by allopurinol drug sensitivity in East Asians.

erotype

References