HLA-B52

HLA-B52

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.{|border="0" cellspacing="0" cellpadding="1" align="left" style="text-align:center; margin-right: 3em; border:1px #ffeebb solid; background:#f8f6f8; "

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.cite journal |author=Sugimura K, Asakura H, Mizuki N, "et al" |title=Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis |journal=Hum. Immunol. |volume=36 |issue=2 |pages=112–8 |year=1993 |month=February |pmid=8096500 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0198-8859(93)90113-F] cite journal |author=Nomura E, Kinouchi Y, Negoro K, "et al" |title=Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis |journal=Genes Immun. |volume=5 |issue=6 |pages=477–83 |year=2004 |month=September |pmid=15215890 |doi=10.1038/sj.gene.6364114 |url=] This form of disease is frequently found with Takayasu's arteritis.cite journal |author=Oyanagi H, Ishihata R, Ishikawa H, "et al" |title=Ulcerative colitis associated with Takayasu's disease |journal=Intern. Med. |volume=33 |issue=2 |pages=127–9 |year=1994 |month=February |pmid=7912572 |doi= |url=http://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/33.127?from=PubMed] cite journal |author=Sato R, Sato Y, Ishikawa H, "et al" |title=Takayasu's disease associated with ulcerative colitis |journal=Intern. Med. |volume=33 |issue=12 |pages=759–63 |year=1994 |month=December |pmid=7718956 |doi= |url=http://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/33.759?from=PubMed]

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease.cite journal |author=Kimura A, Kitamura H, Date Y, Numano F |title=Comprehensive analysis of HLA genes in Takayasu arteritis in Japan |journal=Int. J. Cardiol. |volume=54 Suppl |issue= |pages=S61–9 |year=1996 |month=August |pmid=9119528 |doi= |url=] cite journal |author=Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T |title=DNA typing of HLA-B gene in Takayasu's arteritis |journal=Tissue Antigens |volume=42 |issue=2 |pages=87–90 |year=1993 |month=August |pmid=7903491 |doi= |url=] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.cite journal |author=Kitamura H, Kobayashi Y, Kimura A, Numano F |title=Association of clinical manifestations with HLA-B alleles in Takayasu arteritis |journal=Int. J. Cardiol. |volume=66 Suppl 1 |issue= |pages=S121–6 |year=1998 |month=October |pmid=9951811 |doi= |url=]

References


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