Essentiale is a preparation of essential phospholipids. Essentiale normalizes the metabolism of lipids and proteins, improves the detoxification function of the liver, restores the cellular structure of the liver and retards the producing of conjuctive tissue. Essentiale medications are indicated for the treatment of fatty degeneration of the liver, hepatitis (including toxic hepatitis, liver damage caused by medicines or alcohol abuse), cirrhosis of the liver, disturbances in liver function associated with different illnesses.

Pharmaceutical action

Phospholipids are essential structural components of all cellular membranes. Essential phospholipids (substance EPL) - are the complex substances of natural origin (ethers of cholinephosphoric acid (phosphatidylcholine) and unsaturated fatty acids (linoleic, linolenic, olein)). Essentiale medications possess the membranotropic properties, metabolic and hepatoprotective action; regulates lipid and carbohydrate metabolism. Essential phospholipids increase functional status of the liver.

While the disturbance of the liver metabolism essential phospholipids ensure the entering the high energy phospholipids, which are ideally combined with the endogenous phospholipids . Under the Essentialle phospholipids influence clinical and biochemical liver indexes are improved.

Combination of Essentiale with cordiamin (nikethamide) and viatmin E (50 mg/kg for 35 days) considerably activates the mono-oxigenase, glucoro- and glutathione transferase systems of the liver: and as a result the free-radical processes became less intense [cite journal | title = The action of Essentiale and its combination with cordiamine and vitamin E.| author = IV Zverinskiĭ, VE Karpovich, MI Bushma, LF Legon'kova, NG Mel'nichenko, LI Nechiporenko, VS Nikitin | journal = Eksp Klin Farmakol.| issue = 61(1):33-6 | pages = 212–214 | year =1998 Jan-Feb] .

The spectrum of essential phospholipids' activity in chronic degenerative liver diseases can be described in the following properties:
*recovery and maintaining the consistency of the hepatocytes;
*activation of the phospholipid-depending ferments;
*improvement in the lipids metabolism caused by accelerated synthesis of lipoproteins in the liver;
*activation of synthesis RNA and as a result the normalization of the proteins metabolism;
*increased synthesis of glycogen in the liver;
*improvement in the detoxification function of the liver;
*the conversion of neutral fats and cholesterol into the easily metabolizing forms;
*decreased the fatty infiltration of the hepatocytes.

Common use

Essentiale is used to treat the following diseases:
*Hepatitis(acute and chronic), toxic hepatitis, medicinal and alcoholic hepatitis , poisonings. Hepatic steatosis of different aetiology(in 53.6 % of patients the effect of six-month treatment with Essentiale forte was very good (improvement of all investigated parameters) [cite journal|title= The effect of polyene phosphatidylcholine (Essentiale forte) in the treatment of liver steatosis and ultrasound findings--preliminary study.| publisher = Interní klińika, Institutu postgraduálního vzdélávání ve zdravotnictví, Praha| year = 1994 Jun| issue = 133(12):366-9 |accessdate=2008-07-07 ] diabetes(the data suggests that Essentiale protects and improves liver function in diabeticsubjects with non alcoholic fatty liver [3] [cite journal | author = Poongothai, K Karkuzhali, G Siva Prakash, T Sangeetha, G Saravanan, R Deepa, Sharadha Gopalakrishnan, V Mohan. S Poongothai. Int J Diab Dev Ctries | title = EFFECT OF ESSENTIALE IN DIABETIC SUBJECTS WITH NON - ALCOHOLIC FATTY LIVER | year = 2005 ] ) and chronic infections);
*Disturbance in liver function in somatic diseases;
*Hepatic cirrhosis;
*Necrosis of the liver cells , liver failure, liver coma;
*Pre- and Post- surgical treatment, especially in hepatobiliary area;
*Hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia;
*Diseases of the cardiovascular system: coronary heart disease, stable stenocardia [cite journal |title= The effect of laser therapy and its combination with essentiale on the course of stable stenocardia | publisher= Lik Sprava (0) 0: 72-4| accessdate=2008-07-07 ] , post-infarction condition, disturbance of the cerebral and peripheral circulation, Hypertension, thrombembolia prophylaxis, atherosclerosis, diabetic angiopathy, thrombembolia prophylaxis and fat embolism(solution for injection);
*Digestive system diseases (chronic pancreatitis, gastric and duodenum ulcer;
*Toxicosis of pregnancy(edema, proteinuria и and blood pressure disorders);
*Radiation sickness (radiation syndrome);
*Psoriasis, atomic dermatitis, eczema;
*Pyelonephritis [cite journal | title = Essential phospholipids in the treatment of chronic pyelonephritis.| author = AA Ovchinnikov, VE Tsvettsikh, BA Berdichevskiĭ, VN Lykov, VR Suktanbaev, AV Murychev | journal =Urol Nefrol (Mosk). | year =1996 Jul-Aug | ]
*Prophylaxis of micromegaly.


Essentiale medications are manufactured under 4 trade names:

ESSENTIALE- solution for intravenous injections in vials 5 ml. Essentiale contains essential phospholipids(EPL substance) 250 mg , Pyridoxine chidrochloride 2,5 mg(Vitamin B6), Cyanocobolamine 0,1 mg (Vitamin B12), Sodium Pantothenate 1.5mg, Nicotinamide 25 mg

ESSENTIALE FORTE N- Capsules N30 or N100. One capsule contains essential phospholipids (EPL substance) 300 mg.

ESSENTIALE N. -solution for intravenous injection in vials 5 ml. Essentale N contains essentail phospholipids(EPL substance) 250 mg.

ESSENTIALE FORTE – capsules N50. Essentiale forte contains essential phospholipids(EPL substance) 300 mg, Thiamine mono nitrate(Vitamin B1)6 mg, Riboflavine(Vitamiin B2) 6 mg, Pyridoxine chidrochloride 6mg(Vitamin B6), Cyanocobolamine 0.06 mg (Vitamin B12), Nicotinamide 30mg, Tocopherole acetate 6 mg(Vitamin E).

Contradiction and cautions

Do not use Essentiale in hypersensitivity or allergy to any ingredients of the preparation. The application of Essentiale in newborn children is not safe. During pregnancy women are recommended to consult their health care provider prior to taking Essentiale.

ide effects

In very rare cases it can cause :abdominal pain, nausea, diarrhea and allergic reaction(skin rash).

Recommendation for storage

Capsules should be stored at temperature not more than 20°C.Vials should be stored at 2° - 8°C


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Essentiale — ЭССЕНЦИАЛЕ ( Еssentialе )*. Комплексный препарат, содержащий эссенциальные (необходимые) фосфолипиды диглицериновые эфиры холинфосфорной кислоты и ненасыщенные жирные кислоты: линолевую (около 70 % ), линоленовую и др. (см.Линетол) вместе с… …   Словарь медицинских препаратов

  • Roman Ingarden — Infobox Philosopher region = Western Philosophy era = 20th century philosophy color = #B0C4DE image caption = Portrait of Roman Ingarden by Witkacy name = Roman Ingarden birth = February 5, 1893 (Kraków) death = June 4, 1970 (Kraków, Poland)… …   Wikipedia

  • Sal [1] — Sal (lat.), Salz; S. acetosellae, Sauerkleesalz, oxalsaures Kali; S. Alembrothi, S. sapientiae, Ammoniumquecksilberchlorid; S. alkali volatile, Ammoniak; S. alkali volatile siccum, kohlensaures Ammoniak; S. amarum, S. anglicum, Bittersalz,… …   Meyers Großes Konversations-Lexikon

  • эмфизема легких эссенциальная — (е. pulmonum essentiale) см. Эмфизема легких первичная диффузная …   Большой медицинский словарь

  • E number — This article is about the food additive codes. For other uses, see E number (disambiguation). E numbers are number codes for food additives that have been assessed for use within the European Union (the E prefix stands for Europe ).[1] They are… …   Wikipedia

  • Hepatitis B in China — Hepatitis B is recognized as endemic in China by the World Health Organization (WHO).Liang XF, Chen YS, Wang XJ, et al. A study on the sero epidemiology of hepatitis B in Chinese population aged over 3 years old: the report from Chinese Center… …   Wikipedia

  • Ратификация — (ratificatio, от ratum facere = ratihabitio от ratum habere) утверждение со стороны верховной государственной власти международного договора, заключенного ее уполномоченными. Констатируя соответствие деятельности последних с волей государства, Р …   Энциклопедический словарь Ф.А. Брокгауза и И.А. Ефрона

  • Эмфизема лёгких — I Эмфизема лёгких патологическое состояние легочной ткани, характеризующееся повышенным содержанием в ней воздуха. Различают везикулярную (истинную) и прочие формы Э. л. (интерстициальную; викарную, старческую, врожденную локализованную Э. л.,… …   Медицинская энциклопедия

  • Roman Ingarden — Porträtzeichnung von Witkacy 1937 Roman Witold Ingarden (* 5. Februar 1893 in Krakau; † 14. Juni 1970 ebenda) war ein polnischer Philosoph. Inhal …   Deutsch Wikipedia

  • БЫТИЕ — филос. понятие, обозначающее наличие явлений и предметов самих по себе или как данности в сознании, а не содержательный их аспект. Может пониматься как синоним понятий «существование» и «сущее» или же отличаться от них теми или иными смысловыми… …   Философская энциклопедия

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”