ICRF 193

ICRF 193

chembox new
ImageFile=ICRF 193.pngImageSize=200px
IUPACName=4- [2-(3,5-Dioxo-1-piperazinyl)-1-methylpropyl] piperazine-2,6-dione
OtherNames=
Section1=Chembox Identifiers
CASNo=21416-68-2
PubChem=115150
SMILES=CC(C(C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
MeSHName=ICRF+193
Section2=Chembox Properties
Formula=C12H18N4O4
MolarMass=282.30 g/mol
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3=Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

ICRF 193 is a topoisomerase inhibitor.cite journal |author=Robinson HM, Bratlie-Thoresen S, Brown R, Gillespie DA |title=Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193 |journal=Cell Cycle |volume=6 |issue=10 |pages=1265–7 |year=2007 |month=May |pmid=17495539 |doi= |url=http://www.landesbioscience.com/journals/cc/abstract.php?id=4225]

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  • Type II topoisomerase — Type II topoisomerases cut both strands of the DNA helix simultaneously in order to change the linking number of the molecule. FunctionOnce cut, the ends of the DNA are separated, and a second DNA duplex is passed through the break. Following… …   Wikipedia

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