- Canine Epileptoid Cramping Syndrome
Canine Epileptoid Cramping Syndrome (CECS), also known as Spike's Disease, is a hereditary canine disease with similarities to canine epilepsy, and is often associated with
Border Terrier s. CECS is a recently recognized problem which is theorised as being a metabolic, neurological or muscle disorder, [ [http://www.borderterrier-cecs.com/ Border Terrier CECS] ] but the cause has not yet been identified. [ [http://www.vet.uu.nl/site/viavet/html/enquete_en_voor CECS Info]History
In 1996, Joke Miedema, a Dutch Border Terrier owner, acquired a
puppy named Roughmoor Blue Spike (known as Spike). About a year later, the dog began exhibiting strange symptoms, starting with apparent absentness and occasional staggering. In 2000, Spike began exhibiting more severe symptoms including cramping and epileptic-like fits; tests performed atUtrecht University in 2002 determined that the dog did not have epilepsy. [ [http://www.de-border-terrier.com/spikes-disease/espikesdisease.html Spike's Disease] ]In 1997, German
veterinarian and Border Terrier breeder Diana Plange began receiving calls from people who owned dogs bred by Plange, reporting epileptic-like symptoms. Plange examined more than 100 Border Terriers, eventually determining that the condition was probably hereditary. [ [http://www.borderterrier-cecs.com/cecs_history.htm CECS History] ] Other researchers began to be involved, and several lines of Border Terriers originating in theUK and America were suspected as carriers.By the end of 2001, Spike was having 2-3 epileptoid episodes per week. Owners of cramping dogs began to connect via
Internet groups, including a support group started by Miedema; the condition came to be known as "Spike's Disease." [ [http://www.de-border-terrier.com/spikes-disease/eintro.html Spike's Disease] ] In the spring of 2003, Diana Plange gave the condition the descriptive name Canine Epileptoid Cramping Syndrome. [ [http://www.borderterrier-cecs.com/cecs_history.htm CECS History] ]Breed lines of suspected carriers began to be documented; the first identifiable sufferer was dated to 1974. [ [http://www.borderterrier-cecs.com/cecs_history.htm CECS History] ]
ymptoms
As of 2008, the mode of inheritance has not been determined. [ [http://www.borderterrier-cecs.com/cecs_history.htm CECS History] ]
Symptoms include:
* cramping (often followed by exaggerated stretching)
* staggering
* trembling
* dizziness
* unusually slow or methodical walking
*borborygmus and/or intestinal cramping
* muscle contractionsDogs typically remain alert and responsive during episodes that can last from a few seconds to several minutes. In some dogs, one or two episodes are seen followed by longterm or permanent remission. In others, episodes may be frequent or progressive in frequency and duration.
Treatment
There is currently no known cure for CECS, but some owners have had success with drug and diet therapies.
Drugs
Diazepam and Clorazepate Dipotassium have been used successfully to alleviate cramping in some cases, but have also failed to help in other cases. Scopolamine (Buscopan) rectal suppositories or injections and Gaviscon have been used to alleviate intestinal symptoms. [ [http://www.borderterrier-cecs.com/cecs_treatment_control.htm CECS Treatment/Control] ]Diet
Some owners have had varying levels of success with dietary changes. In most cases, a
gluten -free and/or raw diet is recommended, while some recommend avoiding dairy, eggs, soy, beef, corn, rice, and artificial flavours and colours. [ [http://www.de-border-terrier.com/spikes-disease/efood.html Spike's Disease: Foodl] ] Other owners report success with commercial hypoallergenic formula feeds.Research
Research is currently being conducted to discover the genetic basis of CECS; to develop a diagnostic test or tests; and to find cures or treatments. Studies are underway at the
University of Utrecht , and at theUniversity of Missouri ’s Canine Epilepsy Network.References
Wikimedia Foundation. 2010.