Rs1799913

Infobox Single nucleotide polymorphism
rsid = 1799913
name_1 = A779C
gene = TPH1
chromosome = 11
region = Intron 7
szgene_geneid = 111
szgene_polyid = 586In genetics, rs1799913, also called A779C, is a gene variation—a single nucleotide polymorphism (SNP)— in the TPH1 gene.It is located in intron 7.Cite journal
author = D. A. Nielsen, G. L. Jenkins, K. M. Stefanisko, K. K. Jefferson & D. Goldman
title = Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7
journal = Brain Research. Molecular Brain Research
volume = 45
issue = 1
pages = 145–148
year = 1997
month = April
pmid = 9105682]

The SNP association with schizophrenia has been examined in several studies, though as of 2007 with no definitive conclusion. [Cite journal
author = P. G. Sand
title = Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia
journal = Human Genetics
volume = 122
issue = 3-4
month = November
year = 2007
doi = 10.1007/s00439-007-0383-6
pages = 409–411
url = http://www.springerlink.com/content/0vu146hx11614025/]

One study has found that the SNP may be associated with heroin addiction. [Cite journal
author = David A. Nielsen, Sandra Barral, Dmitri Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek
title = TPH2 and TPH1: association of variants and interactions with heroin addiction
journal = Behavior Genetics
volume = 38
issue = 2
pages = 133–130
year = 2008
month = March
doi = 10.1007/s10519-007-9187-7
pmid = 18181017]

A218C (rs1800532) is another SNP in the same intron in the same gene.

Reference