- FOLFOX
FOLFOX is a
chemotherapy regimen for treatment ofcolorectal cancer , made up of the drugs
* FOL–Folinic acid (leucovorin )
* F –Fluorouracil (5-FU)
* OX –Oxaliplatin (Eloxatin) [ [http://www.cancerhelp.org.uk/help/default.asp?page=15970 Cancer Research UK, CancerHelp UK] ]FOLFOX4
Adjuvant treatment in patients with stage III colon cancer is recommended for 12 cycles, every 2 weeks. The recommended dose schedule given every two weeks is as follows:
Day 1: Eloxatin 85 mg/m² IV infusion in 250-500 mL D5W and leucovorin 200 mg/m² IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.
[
thumb|center|500px|FOLFOX4_regime_[cite journal |author=de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A |title=Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer |journal=J Clin Oncol |volume=18 |issue=16 |pages=2938–47 |year=2000 |pmid=10944126 [http://www.jco.org/cgi/content/full/18/16/2938 HTML] [http://www.jco.org/cgi/reprint/18/16/2938.pdf PDF] Patients with advanced colorectal cancer were given 5-fluorouracil and leukovorin. Those who were also given oxaliplatin were more likely to have a response, and had longer progression-free survival, than patients without oxaliplatin. However, patients with oxaliplatin didn't survive any longer than patients without it. ] [FDA Approval: Eloxatin [oxaliplatin] [http://www.fda.gov/cder/foi/label/2005/021759lbl.pdf PDF] ] ]Premedication with antiemetics, including 5-HT3 blockers with or without dexamethasone, is recommended.
References
*cite journal |author=Goldberg R, Sargent D, Morton R, Fuchs C, Ramanathan R, Williamson S, Findlay B, Pitot H, Alberts S |title=A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer |journal=J Clin Oncol |volume=22 |issue=1 |pages=23–30 |year=2004 |pmid=14665611 |doi=10.1200/JCO.2004.09.046
ee also
*
FOLFIRI
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