Wilder's law of initial value

Wilder's law of initial value

Wilder's law of initial value (LIV) states that "the direction of response of a body function to any agent depends to a large degree on the initial level of that function", proposed by [Joseph Wilder [cite web| url=http://www.ncbi.nlm.nih.gov/pubmed/14000687 |title=Wilder, J. Basimetric approach (law of initial value) to biological rhythms, Annals of the New York Academy of Sciences, 1962, 98, 1211-1228] ] in 1935. It is widely used in physiology.

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