Schiller-Duval body

A Schiller-Duval body is a cellular structure seen by microscope in endodermal sinus tumors. Schiller-Duval bodies are present in approximately 50% of these tumors, and if found are pathognomonic. [ Kumar, Abbas, Fausto. "Pathologic Basis of Disease, 7th edition." Philadelphia; Elsevier-Saunders, 2005. 1042.] They are named for Mathias-Marie Duval and Walter Schiller [ "Schiller-Duval bodies" at whonamedit.com [http://www.whonamedit.com/synd.cfm/2831.html] ] who described them in the late nineteenth century. [Duval M. "Le placenta des rongeurs." Journal de l'anatomie et de la physiologie normales et pathologiques de l'homme et des animaux, Paris, 1891, 27: 24–73, 344–395, 513–612.] [Duval M. "Le placenta des rongeurs." Paris, Felix Alcan, 1892.]

Schiller-Duval bodies are said to resemble a glomerulus. [ Kumar, Abbas, Fausto. "Pathologic Basis of Disease, 7th edition." Philadelphia; Elsevier-Saunders, 2005. 1101.] They have a mesodermal core with a central capillary, all lined by flattened layers of both visceral and parietal cells. Immunofluorescent stain may show eosinophilic hyalin-like globules both inside and outside the cytoplasm that contain AFP and alpha 1-antitrypsin.

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