Xiaoliang Sunney Xie

Xiaoliang Sunney Xie (born 1962 in Beijing, China) is a biochemist. He is Professor of Chemistry and Chemical Biology at Harvard University. Xie is considered as a founding father of single-molecule enzymology. He has made major contributions to CARS microscopy (based on coherent anti-stokes raman scattering). [ [http://www.bioopticsworld.com/display_article/329774/131/none/none/NEWSA/Prof-Sunney-Xie-takes--Zukunftspreis-prize-for-bio-imaging-wor "Bio Optics World" Online News (May 23, 2008): Xie to receive Berthold Leibinger Zukunftspreis] ] .

Xie received a B.S. in chemistry from Peking University, followed by his Ph.D. in 1990 from the University of California at San Diego. He conducted postdoctoral research at the University of Chicago and in 1992 joined Pacific Northwest National Laboratory, where he later became a Chief Scientist. In 1999, he was appointed Professor of Chemistry and Chemical Biology at Harvard University. [ [http://www.lambmedal.org/2007/2007-xie.html Biography of Xie from the Website of the Willis E. Lamb Award (displayed June 4, 2008)] ]

Xie was among the first to conduct fluorescence studies of single molecules at room temperature in the early 1990s. His group has since contributed to the emergence of the field of single-molecule science and its application to biology. In particular, their work has been focusing on single-molecule enzymology, protein conformational dynamics, and single-molecule dynamics in living cells.

Honors and Awards

* 2008: Berthold Leibinger Zukunftspreis for Applied Laser Technology
* 2008: Fellow of the American Academy of Arts and Sciences
* 2007: Willis E. Lamb Award for Laser Sciences and Quantum Optics
* 2006: Fellow of Biophysical Society
* 2006: Fellow of the American Association for the Advancement of Science
* 2004: National Institutes of Health Director's Pioneer Award
* 2003: Raymond and Beverly Sackler Prize in the Physical Sciences
* 1996: Coblentz Award

Selected Literature

* X.S. Xie, P.J. Choi, G.-W. Li, N.K. Lee, G. Lia: "Single-Molecule Approach to Molecular Biology in Living Bacterial Cells." Annu.Rev.Biophys. 37, p417 (2008)
* J. Elf, G. Li, X.S. Xie: "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell." Science 316, p1191 (2007).
* L. Cai, N. Friedman, X.S. Xie: "Stochastic Protein Expression in Individual Cells at the Single Molecule Level" Nature 440, p358 (2006).
* C.L. Evans, E.O. Potma, M. Puoris'haag, D. Côté, C.P. Lin, X.S. Xie: "Chemical Imaging of Tissue in vivo with Video-rate Coherent Anti-Stokes Raman Scattering Microscopy." Proc. Natl. Aca. Sci. 102, p16807 (2005)
* A. Zumbusch, G.R. Holtom, X.S. Xie: "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering." Phys. Rev. Lett. 82, p4142 (1999)
* H.P. Lu, L. Xun, X.S. Xie: "Single-Molecule Enzymatic Dynamics." Science 282, p1877 (1998)
* X.S. Xie, R.C. Dunn: "Probing Single Molecule Dynamics." Science 265, p361 (1994)

References

External links

* [http://bernstein.harvard.edu/ Homepage of the Xie Group at Harvard]