Kinesin 8

Kinesin 8

The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesins. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP-hydrolysis-created energy. The Kinesin 8 family has been shown to play an important role in chromosome alignment during mitosis. Kinesin 8 family members KIF18A in humans [http://www.ncbi.nlm.nih.gov/pubmed/17346968?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Mayr, M.I., Hummer, S., Bormann, J., Gruner, T., Adio, S., Woehlke, G., and T. U. Mayer (2007) Current Biology 17: 488-498.] ] and Kip3 in yeast [http://www.ncbi.nlm.nih.gov/pubmed/16906148?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Gupta, M.L., Jr., Carvalho, P., Roof, D.M., and D. Pellman (2006) Nature. Cell Biology 8: 913-923.] ] have been shown to be "in vivo" plus-end directed microtubule depolymerizers. During prometaphase of mitosis, the microtubules attach to the kinetochores of sister chromatids. Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister chromatids that are unable to align properly (see External Links). [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18267093 Stumpff, J., Dassow, G.V., Wagenbach, M., Asbury, C., and L. Wordeman (2008) Developmental Cell 14(2): 252-262.] ]

References

External links

* [http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2267861&blobname=NIHMS40734-supplement-03.mov Video Illustrations of Kinesin 8 depletion]


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  • Kinesin 13 — The Kinesin 13 Family are a subfamily of the molecular motor proteins known as kinesins. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP hydrolysis created energy.… …   Wikipedia

  • kinesin — A motor protein associated with microtubules; participates in the ATP dependent transport of vesicles and other entities; directs anterograde axonal transport. * * * ki·ne·sin ki nē sən n an ATPase similar to dynein that functions as a motor… …   Medical dictionary

  • kinesin — Cytoplasmic protein (110 kD) that is responsible for moving vesicles and particles towards the distal (plus) end of microtubules. Differs from cytoplasmic dynein (MAP1C) in the direction in which it moves and its relative insensitivity to… …   Dictionary of molecular biology

  • kinesin — noun Any of a class of proteins that convert chemical into mechanical energy and power the movement of vesicles and organelles along microtubules …   Wiktionary

  • Kinesin — Ki|ne|sin [griech. kíne̅sis = Bewegung; ↑ in (3)], das; s, e: ein zelluläres Enzym vom MG 360 000, das die bei der ATP Hydrolyse freigesetzte Energie zum Transport von Zellorganellen innerhalb der Nervenfasern nutzt …   Universal-Lexikon

  • kinesin — ki·ne·sin …   English syllables

  • kinesin — kiˈnēsə̇n noun ( s) Etymology: Greek kinēsis movement, motion + English in more at kinesis : an ATPase similar to dynein that regulates the intracellular transport especially of cell organelles and molecules (as mitochondria and proteins) along… …   Useful english dictionary

  • KNS — kinesin …   Medical dictionary

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