Kinesin 8

Kinesin 8

The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesins. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP-hydrolysis-created energy. The Kinesin 8 family has been shown to play an important role in chromosome alignment during mitosis. Kinesin 8 family members KIF18A in humans [http://www.ncbi.nlm.nih.gov/pubmed/17346968?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Mayr, M.I., Hummer, S., Bormann, J., Gruner, T., Adio, S., Woehlke, G., and T. U. Mayer (2007) Current Biology 17: 488-498.] ] and Kip3 in yeast [http://www.ncbi.nlm.nih.gov/pubmed/16906148?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Gupta, M.L., Jr., Carvalho, P., Roof, D.M., and D. Pellman (2006) Nature. Cell Biology 8: 913-923.] ] have been shown to be "in vivo" plus-end directed microtubule depolymerizers. During prometaphase of mitosis, the microtubules attach to the kinetochores of sister chromatids. Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister chromatids that are unable to align properly (see External Links). [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18267093 Stumpff, J., Dassow, G.V., Wagenbach, M., Asbury, C., and L. Wordeman (2008) Developmental Cell 14(2): 252-262.] ]

References

External links

* [http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2267861&blobname=NIHMS40734-supplement-03.mov Video Illustrations of Kinesin 8 depletion]


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  • kinesin — A motor protein associated with microtubules; participates in the ATP dependent transport of vesicles and other entities; directs anterograde axonal transport. * * * ki·ne·sin ki nē sən n an ATPase similar to dynein that functions as a motor… …   Medical dictionary

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  • kinesin — noun Any of a class of proteins that convert chemical into mechanical energy and power the movement of vesicles and organelles along microtubules …   Wiktionary

  • Kinesin — Ki|ne|sin [griech. kíne̅sis = Bewegung; ↑ in (3)], das; s, e: ein zelluläres Enzym vom MG 360 000, das die bei der ATP Hydrolyse freigesetzte Energie zum Transport von Zellorganellen innerhalb der Nervenfasern nutzt …   Universal-Lexikon

  • kinesin — ki·ne·sin …   English syllables

  • kinesin — kiˈnēsə̇n noun ( s) Etymology: Greek kinēsis movement, motion + English in more at kinesis : an ATPase similar to dynein that regulates the intracellular transport especially of cell organelles and molecules (as mitochondria and proteins) along… …   Useful english dictionary

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