TM4SF5

Transmembrane 4 L six family member 5, also known as TM4SF5, is a human gene.cite web | title = Entrez Gene: TM4SF5 transmembrane 4 L six family member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9032| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.cite web | title = Entrez Gene: TM4SF5 transmembrane 4 L six family member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9032| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Lee SY, Kim YT, Lee MS, "et al." |title=Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment. |journal=Exp. Cell Res. |volume=312 |issue= 16 |pages= 2983-99 |year= 2006 |pmid= 16828471 |doi= 10.1016/j.yexcr.2006.06.001
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kaneko R, Tsuji N, Kamagata C, "et al." |title=Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa. |journal=Am. J. Gastroenterol. |volume=96 |issue= 12 |pages= 3457-8 |year= 2002 |pmid= 11774983 |doi=
*cite journal | author=Wright MD, Ni J, Rudy GB |title=The L6 membrane proteins--a new four-transmembrane superfamily. |journal=Protein Sci. |volume=9 |issue= 8 |pages= 1594-600 |year= 2000 |pmid= 10975581 |doi=
*cite journal | author=Müller-Pillasch F, Wallrapp C, Lacher U, "et al." |title=Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. |journal=Gene |volume=208 |issue= 1 |pages= 25-30 |year= 1998 |pmid= 9479038 |doi=
*cite journal | author=Gress TM, Müller-Pillasch F, Geng M, "et al." |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819-30 |year= 1996 |pmid= 8895530 |doi=

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