DSN1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
Identifiers
Symbols	DSN1; C20orf172; FLJ13346; KNL3; MGC32987; MIS13; dJ469A13.2; hKNL-3
External IDs	OMIM: 609175 MGI: 1914184 HomoloGene: 49806 GeneCards: DSN1 Gene
Gene Ontology Molecular function • protein binding Cellular component • MIS12/MIND type complex • nucleus • chromosome • cytoplasm • cytosol Biological process • M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • chromosome segregation • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79980	66934
Ensembl	ENSG00000149636	ENSMUSG00000027635
UniProt	Q9H410	Q9CYC5
RefSeq (mRNA)	NM_001145315.1	NM_025853.3
RefSeq (protein)	NP_001138787.1	NP_080129.2
Location (UCSC)	Chr 20: 35.38 – 35.4 Mb	Chr 2: 156.82 – 156.83 Mb
PubMed search	[1]	[2]

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.^[1][2]

Function

DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis.^[2][3]

Interactions

DSN1 has been shown to interact with NSL1^[2] and MIS12.^[2][4]

References

1. ^ "Entrez Gene: DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79980. 
2. ^ ^{a b c d} Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. 
3. ^ Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, McGlothen T, Peng W, You T, Sun M, Cui T, Hu R, Dou Z, Zhu J, Xie W, Rao Z, Ding X, Yao X (September 2008). "Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): 26726–36. doi:10.1074/jbc.M804207200. PMC 2546542. PMID 18640974. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2546542. 
4. ^ Cheeseman, Iain M; Niessen Sherry, Anderson Scott, Hyndman Francie, Yates John R, Oegema Karen, Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. (United States) 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=517519. 

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.". J. Cell Biol. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063780. 
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365. 
• Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=517519. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.