PARL

PARL
Presenilin associated, rhomboid-like
Identifiers
Symbols PARL; PSARL; PSARL1; PSENIP2; RHBDS1
External IDs OMIM607858 MGI1277152 HomoloGene10239 GeneCards: PARL Gene
EC number 3.4.21.105
RNA expression pattern
PBB GE PARL 218271 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55486 381038
Ensembl ENSG00000175193 ENSMUSG00000033918
UniProt Q9H300 Q5XJY4
RefSeq (mRNA) NM_001037639.1 NM_001005767.4
RefSeq (protein) NP_001032728.1 NP_001005767.1
Location (UCSC) Chr 3:
183.55 – 183.6 Mb
Chr 16:
20.28 – 20.3 Mb
PubMed search [1] [2]
See also: Prince Albert Radar Laboratory

Presenilins-associated rhomboid-like protein, mitochondrial is a protein that in humans is encoded by the PARL gene [1]. It is a member of the rhomboid family of intramembrane serine proteases [2].

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

References

Further reading


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