CLEC12A

C-type lectin domain family 12, member A, also known as CLEC12A, is a human gene.cite web | title = Entrez Gene: CLEC12A C-type lectin domain family 12, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=160364| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.cite web | title = Entrez Gene: CLEC12A C-type lectin domain family 12, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=160364| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Drickamer K |title=C-type lectin-like domains. |journal=Curr. Opin. Struct. Biol. |volume=9 |issue= 5 |pages= 585–90 |year= 1999 |pmid= 10508765 |doi=
*cite journal | author=van Rhenen A, van Dongen GA, Kelder A, "et al." |title=The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. |journal=Blood |volume=110 |issue= 7 |pages= 2659–66 |year= 2007 |pmid= 17609428 |doi= 10.1182/blood-2007-03-083048
*cite journal | author=Marshall AS, Willment JA, Pyz E, "et al." |title=Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. |journal=Eur. J. Immunol. |volume=36 |issue= 8 |pages= 2159–69 |year= 2006 |pmid= 16838277 |doi= 10.1002/eji.200535628
*cite journal | author=Chen CH, Floyd H, Olson NE, "et al." |title=Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. |journal=Blood |volume=107 |issue= 4 |pages= 1459–67 |year= 2006 |pmid= 16239426 |doi= 10.1182/blood-2005-08-3264
*cite journal | author=Bakker AB, van den Oudenrijn S, Bakker AQ, "et al." |title=C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. |journal=Cancer Res. |volume=64 |issue= 22 |pages= 8443–50 |year= 2005 |pmid= 15548716 |doi= 10.1158/0008-5472.CAN-04-1659
*cite journal | author=Han Y, Zhang M, Li N, "et al." |title=KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. |journal=Blood |volume=104 |issue= 9 |pages= 2858–66 |year= 2004 |pmid= 15238421 |doi= 10.1182/blood-2004-03-0878
*cite journal | author=Marshall AS, Willment JA, Lin HH, "et al." |title=Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14792–802 |year= 2004 |pmid= 14739280 |doi= 10.1074/jbc.M313127200
*cite journal | author=Ebner S, Sharon N, Ben-Tal N |title=Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. |journal=Proteins |volume=53 |issue= 1 |pages= 44–55 |year= 2003 |pmid= 12945048 |doi= 10.1002/prot.10440
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes