Pinacidil

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IUPACName = 3-cyano-1-(4-pyridyl)-2-(1,2,2-trimethylpropyl)guanidine
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CASNo=85371-64-8
PubChem=4826
SMILES=CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
Section2 = Chembox Properties
Formula=C₁₃H₁₉N₅
MolarMass=245.32346
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Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.cite journal | author = Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H | title = Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells | journal = J. Pharmacol. Exp. Ther. | volume = 275 | issue = 2 | pages = 681–92 | year = 1995 | pmid = 7473155 | doi = | url = http://jpet.aspetjournals.org/cgi/content/abstract/275/2/681 | issn = ] It reduces blood pressure and peripheral resistance and produces fluid retention.cite book | author = Reynolds, James Blair; Martindale, William L. | title = The extra pharmacopoeia | publisher = Royal Pharmaceutical Society | location = London | year = 1996 | edition = 31^st edition | pages = 2739 pages | isbn = 0-85369-342-0 | oclc = | doi = ]

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