PDGFRA

PDGFRA
Platelet-derived growth factor receptor, alpha polypeptide
Identifiers
Symbols PDGFRA; CD140A; MGC74795; PDGFR2; RHEPDGFRA
External IDs OMIM173490 MGI97530 HomoloGene31361 GeneCards: PDGFRA Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE PDGFRA 203131 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5156 18595
Ensembl ENSG00000134853 ENSMUSG00000029231
UniProt P16234 Q06BS2
RefSeq (mRNA) NM_006206 NM_011058
RefSeq (protein) NP_006197 NP_035188
Location (UCSC) Chr 4:
55.1 – 55.16 Mb
Chr 5:
75.55 – 75.59 Mb
PubMed search [1] [2]

Alpha-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRA gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.[1]

Contents

Interactions

PDGFRA has been shown to interact with PDGFRB,[2][3] PLCG1,[4] Sodium-hydrogen antiporter 3 regulator 1,[5] Cbl gene,[6] CRK,[7][8] Caveolin 1[9] and PDGFC.[10]

See also

References

  1. ^ "Entrez Gene: PDGFRA platelet-derived growth factor receptor, alpha polypeptide". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5156. 
  2. ^ Rupp, E; Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin C H (Oct. 1994). "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". Eur. J. Biochem. (GERMANY) 225 (1): 29–41. doi:10.1111/j.1432-1033.1994.00029.x. ISSN 0014-2956. PMID 7523122. 
  3. ^ Seifert, R A; Hart C E, Phillips P E, Forstrom J W, Ross R, Murray M J, Bowen-Pope D F (May. 1989). "Two different subunits associate to create isoform-specific platelet-derived growth factor receptors". J. Biol. Chem. (UNITED STATES) 264 (15): 8771–8. ISSN 0021-9258. PMID 2542288. 
  4. ^ Eriksson, A; Nånberg E, Rönnstrand L, Engström U, Hellman U, Rupp E, Carpenter G, Heldin C H, Claesson-Welsh L (Mar. 1995). "Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors". J. Biol. Chem. (UNITED STATES) 270 (13): 7773–81. doi:10.1074/jbc.270.13.7773. ISSN 0021-9258. PMID 7535778. 
  5. ^ Maudsley, S; Zamah A M, Rahman N, Blitzer J T, Luttrell L M, Lefkowitz R J, Hall R A (Nov. 2000). "Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8352–63. doi:10.1128/MCB.20.22.8352-8363.2000. ISSN 0270-7306. PMC 102142. PMID 11046132. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102142. 
  6. ^ Bonita, D P; Miyake S, Lupher M L, Langdon W Y, Band H (Aug. 1997). "Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity". Mol. Cell. Biol. (UNITED STATES) 17 (8): 4597–610. ISSN 0270-7306. PMC 232313. PMID 9234717. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232313. 
  7. ^ Yokote, K; Hellman U, Ekman S, Saito Y, Rönnstrand L, Saito Y, Heldin C H, Mori S (Mar. 1998). "Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins". Oncogene (ENGLAND) 16 (10): 1229–39. doi:10.1038/sj.onc.1201641. ISSN 0950-9232. PMID 9546424. 
  8. ^ Matsumoto, T; Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, Matsuda M, Saito Y, Mori S (Apr. 2000). "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 28–33. doi:10.1006/bbrc.2000.2374. ISSN 0006-291X. PMID 10733900. 
  9. ^ Yamamoto, M; Toya Y, Jensen R A, Ishikawa Y (Mar. 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res. (UNITED STATES) 247 (2): 380–8. doi:10.1006/excr.1998.4379. ISSN 0014-4827. PMID 10066366. 
  10. ^ Gilbertson, D G; Duff M E, West J W, Kelly J D, Sheppard P O, Hofstrand P D, Gao Z, Shoemaker K, Bukowski T R, Moore M, Feldhaus A L, Humes J M, Palmer T E, Hart C E (Jul. 2001). "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor". J. Biol. Chem. (United States) 276 (29): 27406–14. doi:10.1074/jbc.M101056200. ISSN 0021-9258. PMID 11297552. 

Further reading

  • Hart CE, Bowen-Pope DF (1990). "Platelet-derived growth factor receptor: current views of the two-subunit model". J. Invest. Dermatol. 94 (6 Suppl): 53S–57S. doi:10.1111/1523-1747.ep12875065. PMID 2161888. 
  • Corless CL, Schroeder A, Griffith D, et al. (2005). "PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib". J. Clin. Oncol. 23 (23): 5357–64. doi:10.1200/JCO.2005.14.068. PMID 15928335. 
  • Lasota J, Miettinen M (2007). "KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)". Semin Diagn Pathol 23 (2): 91–102. doi:10.1053/j.semdp.2006.08.006. PMID 17193822. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • FIP1L1 — FIP1 like 1 (S. cerevisiae), also known as FIP1L1, is a human gene.cite web | title = Entrez Gene: FIP1L1 FIP1 like 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=81608| accessdate = ]… …   Wikipedia

  • Síndrome hipereosinofílico — Clasificación y recursos externos CIE 10 D72.1 (ILDS D72.12) CIE 9 288.3 CIE O 9964/3 …   Wikipedia Español

  • Crenolanib — IUPAC name 1 (2 {5 [(3 Methyloxetan 3 yl)methoxy] 1H benzimidazol 1 yl}quinolin 8 yl)piperidin 4 amine …   Wikipedia

  • Tyrosinkinase-Inhibitor — Tyrosinkinase Inhibitoren sind neuartige Medikamenten Wirkstoffe, die bisher vor allem bei Tumorerkrankungen zum Einsatz kommen. Seit etwa den 1990er Jahren ist bekannt, dass dysregulierte Tyrosinkinasen häufig eine Schlüsselrolle bei der… …   Deutsch Wikipedia

  • Tyrosinkinaseinhibitor — Tyrosinkinase Inhibitoren sind neuartige Medikamenten Wirkstoffe, die bisher vor allem bei Tumorerkrankungen zum Einsatz kommen. Seit etwa den 1990er Jahren ist bekannt, dass dysregulierte Tyrosinkinasen häufig eine Schlüsselrolle bei der… …   Deutsch Wikipedia

  • Gastrointestinal stromal tumor — Infobox Disease Name = Gastrointestinal stromal tumor Caption = Histopathologic image of gastrointestinal stromal tumour of the stomach. Hematoxylin eosin stain. DiseasesDB = 33849 ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj =… …   Wikipedia

  • Hypereosinophilic syndrome — Infobox Disease Name = Hypereosinophilic syndrome Caption = An eosinophil, the white blood cell involved in hypereosinophilic syndrome, seen amongst red blood cells. DiseasesDB = ICD10 = ICD10|D|72|1|d|70 (ILDS D72.12) ICD9 = ICD9|288.3 ICDO =… …   Wikipedia

  • Platelet-derived growth factor receptor — platelet derived growth factor receptor, alpha polypeptide Identifiers Symbol PDGFRA Entrez 5156 HUGO …   Wikipedia

  • CD117 — CD117, also called KIT or C kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow).… …   Wikipedia

  • Chronic eosinophilic leukemia — Classification and external resources ICD O: 9964/3 Chronic eosinophilic leukemia (CEL) is a disease in which too many eosinophils (a type of white blood cell) are found in the bone marrow, blood, and other tissues. CEL may stay the same for many …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”