MS4A2

MS4A2

Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide), also known as MS4A2, is a human gene.cite web | title = Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2206| accessdate = ]

PBB_Summary
section_title =
summary_text = The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.cite web | title = Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2206| accessdate = ]

ee also

* FcεRI

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jouvin MH, Numerof RP, Kinet JP |title=Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI. |journal=Semin. Immunol. |volume=7 |issue= 1 |pages= 29–35 |year= 1995 |pmid= 7612892 |doi=
*cite journal | author=Wilson BS, Pfeiffer JR, Oliver JM |title=FcepsilonRI signaling observed from the inside of the mast cell membrane. |journal=Mol. Immunol. |volume=38 |issue= 16-18 |pages= 1259–68 |year= 2003 |pmid= 12217393 |doi=
*cite journal | author=Kraft S, Rana S, Jouvin MH, Kinet JP |title=The role of the FcepsilonRI beta-chain in allergic diseases. |journal=Int. Arch. Allergy Immunol. |volume=135 |issue= 1 |pages= 62–72 |year= 2004 |pmid= 15316148 |doi= 10.1159/000080231
*cite journal | author=Maekawa K, Imagawa N, Tanaka Y, Harada S |title=Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. |journal=FEBS Lett. |volume=302 |issue= 2 |pages= 161–5 |year= 1992 |pmid= 1386024 |doi=
*cite journal | author=Bieber T, de la Salle H, Wollenberg A, "et al." |title=Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). |journal=J. Exp. Med. |volume=175 |issue= 5 |pages= 1285–90 |year= 1992 |pmid= 1533242 |doi=
*cite journal | author=Küster H, Zhang L, Brini AT, "et al." |title=The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 12782–7 |year= 1992 |pmid= 1535625 |doi=
*cite journal | author=Le Coniat M, Kinet JP, Berger R |title=The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23. |journal=Immunogenetics |volume=32 |issue= 3 |pages= 183–6 |year= 1990 |pmid= 2146219 |doi=
*cite journal | author=Tedder TF, Streuli M, Schlossman SF, Saito H |title=Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 1 |pages= 208–12 |year= 1988 |pmid= 2448768 |doi=
*cite journal | author=Paolini R, Renard V, Vivier E, "et al." |title=Different roles for the Fc epsilon RI gamma chain as a function of the receptor context. |journal=J. Exp. Med. |volume=181 |issue= 1 |pages= 247–55 |year= 1995 |pmid= 7528770 |doi=
*cite journal | author=Shirakawa T, Li A, Dubowitz M, "et al." |title=Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. |journal=Nat. Genet. |volume=7 |issue= 2 |pages= 125–9 |year= 1994 |pmid= 7920628 |doi= 10.1038/ng0694-125
*cite journal | author=Kihara H, Siraganian RP |title=Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. |journal=J. Biol. Chem. |volume=269 |issue= 35 |pages= 22427–32 |year= 1994 |pmid= 8071371 |doi=
*cite journal | author=Sandford AJ, Shirakawa T, Moffatt MF, "et al." |title=Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. |journal=Lancet |volume=341 |issue= 8841 |pages= 332–4 |year= 1993 |pmid= 8094113 |doi=
*cite journal | author=Szepetowski P, Gaudray P |title=FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1. |journal=Genomics |volume=19 |issue= 2 |pages= 399–400 |year= 1994 |pmid= 8188278 |doi=
*cite journal | author=Daniels SE, Bhattacharrya S, James A, "et al." |title=A genome-wide search for quantitative trait loci underlying asthma. |journal=Nature |volume=383 |issue= 6597 |pages= 247–50 |year= 1996 |pmid= 8805698 |doi= 10.1038/383247a0
*cite journal | author=Hill MR, Cookson WO |title=A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. |journal=Hum. Mol. Genet. |volume=5 |issue= 7 |pages= 959–62 |year= 1997 |pmid= 8817330 |doi=
*cite journal | author=Shirakawa T, Mao XQ, Sasaki S, "et al." |title=Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. |journal=Hum. Mol. Genet. |volume=5 |issue= 8 |pages= 1129–30 |year= 1997 |pmid= 8842731 |doi=
*cite journal | author=Shirakawa T, Mao XQ, Sasaki S, "et al." |title=Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. |journal=Hum. Mol. Genet. |volume=5 |issue= 12 |pages= 2068 |year= 1997 |pmid= 8968765 |doi=
*cite journal | author=Hendricks-Taylor LR, Motto DG, Zhang J, "et al." |title=SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1363–7 |year= 1997 |pmid= 8995445 |doi=
*cite journal | author=Kanzaki M, Lindorfer MA, Garrison JC, Kojima I |title=Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14733–9 |year= 1997 |pmid= 9169438 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Membrane-spanning 4A — is a family of genes.[1] Members include: MS4A1 (better known as CD20 ) MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18 References ^ Liang Y …   Wikipedia

  • Myelin — Structure of a typical neuron Myelin sheath Dendrite …   Wikipedia

  • Bacteriocin — Bacteriocins are proteinaceous toxins produced by bacteria to inhibit the growth of similar or closely related bacterial strain(s). They are typically considered to be narrow spectrum antibiotics, though this has been debated.[1] They are… …   Wikipedia

  • Melittin — Melittin[1] Identifiers CAS number …   Wikipedia

  • Pulmonary surfactant — Diagram of the alveoli with both cross section and external view Pulmonary surfactant is a surface active lipoprotein complex (phospholipoprotein) formed by type II alveolar cells. The proteins and lipids that surfactant comprises have both a… …   Wikipedia

  • Myelin basic protein — Rendering of MBP from PDB 1BX2 …   Wikipedia

  • Myelin oligodendrocyte glycoprotein — Crystal structure of rat myelin oligodendrocyte glycoprotein.[1] …   Wikipedia

  • Dysferlin — Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) Identifiers Symbols DYSF; FER1L1; FLJ00175; FLJ90168; LGMD2B External IDs …   Wikipedia

  • Merlin (protein) — Neurofibromin 2 (merlin) PDB rendering based on 1h4r …   Wikipedia

  • FcεRI — protein Name=Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide caption= width= HGNCid=3609 Symbol=FCER1A AltSymbols=FCE1A EntrezGene=2205 OMIM=147140 RefSeq=NM 002001 UniProt=P12319 PDB= ECnumber= Chromosome=1 Arm=q Band=23… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”