- DLEU2
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Deleted in lymphocytic leukemia 2 (non-protein coding) Identifiers Symbols DLEU2; 1B4; BCMSUN; DLB2; LEU2; MGC88287; MIR15AHG; NCRNA00022; RFP2OS; TRIM13OS External IDs OMIM: 605766 GeneCards: DLEU2 Gene Gene Ontology Orthologs Species Human Mouse Entrez 8847 n/a Ensembl n/a n/a UniProt n/a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search [1] n/a Deleted in lymphocytic leukemia 1 (non-protein coding) is a long non-coding RNA that in humans is encoded by the DLEU2 gene. In humans it is located on chromosome 13q14.[1][2][3] The DLEU2 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.[1]
See also
References
- ^ a b Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grander D, Iyengar A, Baranova A, Kashuba V, Merup M, Wu X, Gardiner A, Mullenbach R, Poltaraus A, Hultstrom AL, Juliusson G, Chapman R, Tiller M, Cotter F, Gahrton G, Yankovsky N, Zabarovsky E, Einhorn S, Oscier D (Dec 1997). "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia". Oncogene 15 (20): 2463–73. doi:10.1038/sj.onc.1201643. PMID 9395242.
- ^ Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Dohner H, Stilgenbauer S, Lichter P (Nov 2000). "BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like". Int J Cancer 88 (5): 692–7. doi:10.1002/1097-0215(20001201)88:5<692::AID-IJC2>3.0.CO;2-3. PMID 11072235.
- ^ "Entrez Gene: DLEU2 deleted in lymphocytic leukemia, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8847.
Further reading
- Kapanadze B, Makeeva N, Corcoran M, et al. (2001). "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14.". Genomics 70 (3): 327–34. doi:10.1006/geno.2000.6386. PMID 11161783.
- Migliazza A, Bosch F, Komatsu H, et al. (2001). "Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.". Blood 97 (7): 2098–104. doi:10.1182/blood.V97.7.2098. PMID 11264177.
- Bullrich F, Fujii H, Calin G, et al. (2001). "Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene.". Cancer Res. 61 (18): 6640–8. PMID 11559527.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Baranova A, Hammarsund M, Ivanov D, et al. (2004). "Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS.". Gene 321: 103–12. doi:10.1016/j.gene.2003.08.007. PMID 14636997.
- Corcoran MM, Hammarsund M, Zhu C, et al. (2004). "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse.". Genes Chromosomes Cancer 40 (4): 285–97. doi:10.1002/gcc.20046. PMID 15188451.
- Skoblov M, Shakhbazov K, Oshchepkov D, et al. (2006). "Human RFP2 gene promoter: unique structure and unusual strength.". Biochem. Biophys. Res. Commun. 342 (3): 859–66. doi:10.1016/j.bbrc.2006.01.187. PMC 1994241. PMID 16499869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1994241.
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