COG2

COG2
Component of oligomeric golgi complex 2
Identifiers
Symbols COG2; LDLC
External IDs OMIM606974 MGI1923582 HomoloGene7206 GeneCards: COG2 Gene
RNA expression pattern
PBB GE COG2 203073 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22796 76332
Ensembl ENSG00000135775 ENSMUSG00000031979
UniProt Q14746 Q3TAN4
RefSeq (mRNA) NM_001145036.1 NM_029746.3
RefSeq (protein) NP_001138508.1 NP_084022.2
Location (UCSC) Chr 1:
230.78 – 230.83 Mb
Chr 8:
127.04 – 127.08 Mb
PubMed search [1] [2]

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.[1][2]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).[supplied by OMIM][2]

Interactions

COG2 has been shown to interact with COG4[3] and COG3.[4]

References

  1. ^ Podos SD, Reddy P, Ashkenas J, Krieger M (Dec 1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function". J Cell Biol 127 (3): 679–91. doi:10.1083/jcb.127.3.679. PMC 2120235. PMID 7962052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120235. 
  2. ^ a b "Entrez Gene: COG2 component of oligomeric golgi complex 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22796. 
  3. ^ Loh, Eva; Hong Wanjin (Jun. 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703. 
  4. ^ Loh, Eva; Hong Wanjin (Jun. 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. (United States) 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878. 

Further reading


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