DCLRE1A

DNA cross-link repair 1A
Identifiers
Symbols	DCLRE1A; KIAA0086; PSO2; SNM1; SNM1A
External IDs	OMIM: 609682 MGI: 1930042 HomoloGene: 8920 GeneCards: DCLRE1A Gene
Gene Ontology Molecular function • hydrolase activity Cellular component • nucleus Biological process • nucleotide-excision repair • cell cycle • mitosis • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9937	55947
Ensembl	ENSG00000198924	ENSMUSG00000025077
UniProt	Q6PJP8	Q9JIC3
RefSeq (mRNA)	NM_014881	NM_018831.3
RefSeq (protein)	NP_055696	NP_061301.2
Location (UCSC)	Chr 10: 115.59 – 115.61 Mb	Chr 19: 56.6 – 56.62 Mb
PubMed search	[1]	[2]

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.^[1][2][3]

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM]^[3]

References

1. ^ Demuth I, Digweed M (Nov 1998). "Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086". Mutat Res 409 (1): 11–6. PMID 9806498. 
2. ^ Hejna J, Philip S, Ott J, Faulkner C, Moses R (Oct 2007). "The hSNM1 protein is a DNA 5'-exonuclease". Nucleic Acids Res 35 (18): 6115–23. doi:10.1093/nar/gkm530. PMC 2094091. PMID 17804464. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2094091. 
3. ^ ^{a b} "Entrez Gene: DCLRE1A DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9937. 

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527. 
• Dronkert ML, de Wit J, Boeve M, et al. (2000). "Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C". Mol. Cell. Biol. 20 (13): 4553–61. doi:10.1128/MCB.20.13.4553-4561.2000. PMC 85844. PMID 10848582. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85844. 
• Richie CT, Peterson C, Lu T, et al. (2003). "hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage". Mol. Cell. Biol. 22 (24): 8635–47. doi:10.1128/MCB.22.24.8635-8647.2002. PMC 139863. PMID 12446782. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139863. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zhang X, Richie C, Legerski RJ (2003). "Translation of hSNM1 is mediated by an internal ribosome entry site that upregulates expression during mitosis". DNA Repair (Amst.) 1 (5): 379–90. doi:10.1016/S1568-7864(02)00015-0. PMID 12509242. 
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Akhter S, Richie CT, Deng JM, et al. (2005). "Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress". Mol. Cell. Biol. 24 (23): 10448–55. doi:10.1128/MCB.24.23.10448-10455.2004. PMC 529044. PMID 15542852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=529044. 
• Ishiai M, Kimura M, Namikoshi K, et al. (2004). "DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation". Mol. Cell. Biol. 24 (24): 10733–41. doi:10.1128/MCB.24.24.10733-10741.2004. PMC 533992. PMID 15572677. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=533992.