AIFM2

Apoptosis-inducing factor, mitochondrion-associated, 2, also known as AIFM2, is a human gene.cite web | title = Entrez Gene: AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84883| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene has significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. Overexpression of this gene has been shown to induce apoptosis. The expression of this gene is found to be induced by tumor suppressor protein p53 in colon caner cells.cite web | title = Entrez Gene: AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84883| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Horikoshi N, Cong J, Kley N, Shenk T |title=Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 864–9 |year= 1999 |pmid= 10441517 |doi= 10.1006/bbrc.1999.1123
*cite journal | author=Wu M, Xu LG, Li X, "et al." |title=AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25617–23 |year= 2002 |pmid= 11980907 |doi= 10.1074/jbc.M202285200
*cite journal | author=Ohiro Y, Garkavtsev I, Kobayashi S, "et al." |title=A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 163–71 |year= 2002 |pmid= 12135761 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang W, Li D, Mehta JL |title=Role of AIF in human coronary artery endothelial cell apoptosis. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=286 |issue= 1 |pages= H354–8 |year= 2004 |pmid= 14684364 |doi= 10.1152/ajpheart.00579.2003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Wu M, Xu LG, Su T, "et al." |title=AMID is a p53-inducible gene downregulated in tumors. |journal=Oncogene |volume=23 |issue= 40 |pages= 6815–9 |year= 2004 |pmid= 15273740 |doi= 10.1038/sj.onc.1207909
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Marshall KR, Gong M, Wodke L, "et al." |title=The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 30735–40 |year= 2005 |pmid= 15958387 |doi= 10.1074/jbc.M414018200
*cite journal | author=Varecha M, Amrichová J, Zimmermann M, "et al." |title=Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells. |journal=Apoptosis |volume=12 |issue= 7 |pages= 1155–71 |year= 2007 |pmid= 17347867 |doi= 10.1007/s10495-007-0061-0
*cite journal | author=Gong M, Hay S, Marshall KR, "et al." |title=DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. |journal=J. Biol. Chem. |volume=282 |issue= 41 |pages= 30331–40 |year= 2007 |pmid= 17711848 |doi= 10.1074/jbc.M703713200

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