PAG1

PAG1
Phosphoprotein associated with glycosphingolipid microdomains 1
Identifiers
Symbols PAG1; CBP; FLJ37858; MGC138364; PAG
External IDs OMIM605767 MGI2443160 HomoloGene10198 GeneCards: PAG1 Gene
RNA expression pattern
PBB GE PAG1 gnf1h00294 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55824 94212
Ensembl ENSG00000076641 ENSMUSG00000027508
UniProt Q9NWQ8 Q3U1F9
RefSeq (mRNA) NM_018440 XM_976665
RefSeq (protein) NP_060910 XP_981759
Location (UCSC) Chr 8:
81.88 – 82.02 Mb
Chr 3:
9.69 – 9.83 Mb
PubMed search [1] [2]

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[1][2]

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[2]

Interactions

PAG1 has been shown to interact with FYN,[1] C-src tyrosine kinase,[1] Sodium-hydrogen antiporter 3 regulator 1[3] and Abl gene.[4]

References

  1. ^ a b c Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2213442. 
  2. ^ a b "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55824. 
  3. ^ Brdicková, N; Brdicka T, Andera L, Spicka J, Angelisová P, Milgram S L, Horejsí V (Oct. 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. (Netherlands) 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085. 
  4. ^ Wen, S T; Van Etten R A (Oct. 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. (UNITED STATES) 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. ISSN 0890-9369. PMC 316562. PMID 9334312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316562. 

Further reading


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